| Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies. | |
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MedLine Citation:
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PMID: 16173235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings. METHODS: Serum samples from 1,135 Japanese patients with various autoimmune diseases were screened for anti-PL-7 antibodies using RNA and protein immunoprecipitation assays. The patients whose sera contained anti-PL-7 antibodies were assessed regarding clinical symptoms and clinical course. RESULTS: Sera from seven patients were found to have anti-PL-7 antibodies. These autoantibodies were associated with polymyositis/dermatomyositis (PM/DM) and/or interstitial lung disease (ILD). The clinical diagnoses of these seven patients were PM - systemic sclerosis (SSc) overlap (5 patients), DM (1 patient) and idiopathic pulmonary fibrosis (IPF) (1 patient). All patients had ILD with a chronic course and six also had arthritis (85%) and five sclerodactyly (71%). CONCLUSIONS: These results indicate that anti-PL-7 autoantibodies are closely associated with PM-SSc overlap as well as ILD, arthritis and sclerodactyly in our series of Japanese patients. |
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Authors:
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S Sato; M Hirakata; M Kuwana; K Nakamura; A Suwa; S Inada; T Mimori; Y Ikeda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 23 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2005 Sep-Oct |
Date Detail:
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Created Date: 2005-09-21 Completed Date: 2005-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: 609-15 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan. shins@sc.itc.keio.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asian Continental Ancestry Group Autoantibodies / immunology* Autoimmune Diseases / ethnology, immunology* Dermatomyositis / ethnology, immunology Female Humans Lung Diseases, Interstitial / ethnology, immunology Male Middle Aged Polymyositis / ethnology, immunology Pulmonary Fibrosis / ethnology, immunology Scleroderma, Systemic / ethnology, immunology Threonine-tRNA Ligase / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; EC 6.1.1.3/Threonine-tRNA Ligase |
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