Document Detail


Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.
MedLine Citation:
PMID:  9003978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the case of a mentally retarded 30 y.o. patient with partial trisomy of chromosome 9, affected by epilepsy. Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE. Gradual withdrawal of AED, obtained clinical remission. The possibility that the chromosomal abnormality of the patient was responsible for the three rare complications observed during AED therapy is considered.
Authors:
G L Gigli; A Scalise; G Silvestri; M Diomedi; F Placidi; M G Pomponi; C Masala
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  87     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-9     Citation Subset:  IM    
Affiliation:
Clinica Neurologica, Università Tor Vergata, Roma, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticonvulsants / adverse effects*,  therapeutic use
Brain / pathology
Carbamazepine / adverse effects*,  therapeutic use
Chromosome Aberrations* / genetics*,  pathology
Chromosome Disorders*
Chromosomes, Human, Pair 9*
Diagnostic Errors
Electroencephalography
Epilepsy, Generalized / drug therapy*,  genetics,  pathology
Ethosuximide / therapeutic use
Female
Hodgkin Disease / diagnosis
Humans
Lupus Erythematosus, Systemic / chemically induced*,  genetics
Magnetic Resonance Imaging
Mental Retardation / genetics,  pathology
Myoclonus / chemically induced*,  genetics
Phenytoin / adverse effects*,  therapeutic use
Pseudolymphoma / chemically induced*,  diagnosis,  genetics
Trisomy*
Valproic Acid / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine; 57-41-0/Phenytoin; 77-67-8/Ethosuximide; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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