| Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter's syndrome. | |
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MedLine Citation:
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PMID: 22184514 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Klinefelter's syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia-M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corresponding to Klinefelter's syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically. |
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Authors:
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Vanya Slavcheva; Tzvetan Lukanov; Gueorgui Balatsenko; Svetlana Angelova; Antonio Antonov; Lachezar Bogdanov; Nikolay Tsvetkov |
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Publication Detail:
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Type: Journal Article Date: 2010-12-22 |
Journal Detail:
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Title: Hematology reports Volume: 2 ISSN: 2038-8330 ISO Abbreviation: Hematol Rep Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101556723 Medline TA: Hematol Rep Country: Italy |
Other Details:
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Languages: eng Pagination: e11 Citation Subset: - |
Affiliation:
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Hematology clinic, University Hospital, Pleven, Bulgaria; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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