| Clinical cardiotoxicity of 5-fluorouracil. | |
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MedLine Citation:
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PMID: 8300889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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5-Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems. It also has cardiac toxicity, but this is perceived to be rare. During a 16-month period from January 1990 through April 1991, approximately 910 patients were treated with 5-fluorouracil. Five of these developed life-threatening toxicity consistent with coronary artery spasm for an incidence of .55%. The acute events occurred on the third or fourth day of the 5-day infusion and after the fourth intravenous bolus in the patient on bolus therapy. Each of the patients had ST elevation and ventricular arrhythmias, four had acute myocardial infarction, and two had cardiac arrests. In these cases and those previously reported, cardiac toxicity is consistent with drug- or metabolite-mediated increases in coronary vasomotor tone and spasm, leading to the full spectrum of signs and symptoms of myocardial ischemia in susceptible individuals. |
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Authors:
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D L Keefe; N Roistacher; M K Pierri |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 33 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-03-04 Completed Date: 1994-03-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1060-70 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Memorial Sloan-Kettering Cancer Center, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arrhythmias, Cardiac / chemically induced Coronary Vasospasm / chemically induced Electrocardiography / drug effects Female Fluorouracil / administration & dosage, adverse effects*, therapeutic use Heart Arrest / chemically induced Heart Diseases / chemically induced* Humans Infusions, Intravenous Male Middle Aged Myocardial Infarction / chemically induced Neoplasms / drug therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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