| Clinical and biological significance of clonal macrophage detection in hemophagocytic syndrome. | |
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MedLine Citation:
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PMID: 12658753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By using the method of clonal analysis the evidence to prove that Hemophagocytic syndrome (HPS) is reactive or malignant was investigated to probe into the pathogenesis of HPS and its relations with clinical prognosis. The macrophages abnormally proliferated in bone marrow were isolated. Electrophoresis analysis was made after DNA extraction, enzyme restriction of human ardrogen receptor (HUMARA) genetic locus, and PCR amplification. In the 9 specimens, clonal proliferation was found in 2 cases and nonclonal proliferation in 7. Among the 7 cases of nonclonal proliferation, 3 were voluntarily discharged without clinical outcome, 2 cases fully recovered after 2-3 week treatment of large dose gamma globulin intravenous drip and hormone therapy, 1 case died at the 43th day after the hormone and anti-infection therapy, and one case was found to have granular leukoblast in peripheral blood after 3 weeks and diagnosed as having M2a after bone puncture. For the two patients with clonal proliferation, one obtained remission after chemotherapy and the other was died after 32 days without chemotherapy. It was concluded that there do exist clonal or malignant proliferation in HPS, so not every case is reactive. |
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Authors:
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Wen Lin; Yan Xiao; Hongbao Fei |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban Volume: 22 ISSN: 1672-0733 ISO Abbreviation: J. Huazhong Univ. Sci. Technol. Med. Sci. Publication Date: 2002 |
Date Detail:
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Created Date: 2003-03-27 Completed Date: 2004-07-22 Revised Date: 2006-12-14 |
Medline Journal Info:
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Nlm Unique ID: 101169627 Medline TA: J Huazhong Univ Sci Technolog Med Sci Country: China |
Other Details:
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Languages: eng Pagination: 126-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Clone Cells Histiocytosis, Non-Langerhans-Cell / blood*, therapy Humans Infant Macrophages / pathology* gamma-Globulins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/gamma-Globulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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