Document Detail

Clinical biochemistry of pregnancy.
MedLine Citation:
PMID:  9055057     Owner:  NLM     Status:  MEDLINE    
Major adaptations in maternal physiology and metabolism are required for successful pregnancy outcome. Hormonal changes initiated even before conception significantly alter maternal biochemistry early in pregnancy. Steroid hormones, peptide hormones, and prostaglandins interact to expand blood and plasma volume and modulate the maternal capacity to supply energy and nutrients to the fetoplacental unit. As gestation progresses, reference ranges for the concentration of many biochemical parameters change significantly from those found in the nonpregnant state. Gestation-specific reference ranges are essential for correct interpretation of tests used in screening, diagnosis, and monitoring during pregnancy. The use of clinical laboratory tests in the management of high-risk pregnancy are discussed from the perspective of testing before conception and during pregnancy.
G Lockitch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in clinical laboratory sciences     Volume:  34     ISSN:  1040-8363     ISO Abbreviation:  Crit Rev Clin Lab Sci     Publication Date:  1997  
Date Detail:
Created Date:  1997-05-20     Completed Date:  1997-05-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8914816     Medline TA:  Crit Rev Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-139     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, University of British Columbia, Canada.
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MeSH Terms
Adaptation, Physiological
Hormones / metabolism
Pregnancy / metabolism*,  physiology
Pregnancy Complications / diagnosis
Reference Values
Reg. No./Substance:

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