Document Detail

Clinical and biochemical pregnancy in two respective recipients without ovarian function following gamete intrafallopian transfers using oocytes from a single donor.
MedLine Citation:
PMID:  2237389     Owner:  NLM     Status:  MEDLINE    
Infertility resulting from premature ovarian failure in two independent patients was treated using a combination of steroid replacement, oocyte donation and gamete intrafallopian transfer (GIFT). Following ovarian stimulation four oocytes were retrieved from a volunteer donor undergoing simultaneous laparoscopic sterilisation. Two oocytes were subsequently replaced into each recipient's fallopian tube together with capacitated sperm from their respective husbands. In one recipient (Turner's syndrome) an intrauterine sac with fetal heart present was observed by ultrasound six weeks post GIFT whereas in the second recipient (premature menopause) plasma beta-hCG reached a peak value of 954mIU/ml eighteen days after GIFT before decreasing rapidly in the absence of ultrasound evidence of pregnancy. Intramuscular administration of progesterone appeared to be necessary during the post-GIFT period for maintenance of pregnancy. The above treatment was carried out on a predominantly out-patient basis in a small assisted conception unit based in a teaching hospital.
T Oskarsson; D H Edgar; K M Whalley; J A Mills
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scottish medical journal     Volume:  35     ISSN:  0036-9330     ISO Abbreviation:  Scott Med J     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983335R     Medline TA:  Scott Med J     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  114-5     Citation Subset:  IM    
Unit of Reproductive Medicine, Ninewells Hospital and Medical School, Dundee.
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MeSH Terms
Gamete Intrafallopian Transfer*
Infertility, Female*
Prenatal Diagnosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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