Document Detail

Clinical and biochemical parameters related to cardiovascular disease after Helicobacter pylori eradication.
MedLine Citation:
PMID:  20087284     Owner:  NLM     Status:  MEDLINE    
AIM: Since the major established risk factors explain the pathogenesis of ischemic heart disease (IHD) in a proportion of cases, it is crucial to search for other causal mechanisms. The possible link between IHD and Helicobacter pylori (H.pylori) infection has been reported. However, the precise mechanism of this potential relationship, by a proinflammatory activity or metabolic disorder, is unclear. In order to investigate this issue, the authors assessed changes in clinical and biochemical parameters related to IHD after bacterial eradication. METHODS: A total of 496 patients (281 males; mean age 59.7+/-2.3) with H.pylori-positive dyspepsia and/or peptic ulcer were studied after cure of the bacterium. H.pylori status was determined by histology or 13C-urea breath testing. Examinations for body mass index, diastolic blood pressure and blood testing (C-reactive protein, fibrinogen, triglycerides, total cholesterol, high-density and low-density lipoprotein cholesterol, fasting glucose) were performed before eradication and annually for up to five years thereafter. For statistical analyses, the Student's t test was performed. RESULTS: HDL-C increased (P=0.02) while C-reactive protein and fibrinogen levels diminished (P<0.0001) significantly. BMI and diastolic blood pressure increased in a significant (P=0.032 and P=0.039 respectively) manner compared to baseline. CONCLUSIONS: H.pylori eradication is associated with modification of some clinical and biochemical parameters related to IHD during a follow-up of five years. There is a need for large interventional randomized studies in order to prove a causal association.
R Pellicano; E Oliaro; S Fagoonee; M Astegiano; M Berrutti; G Saracco; A Smedile; A Repici; N Leone; A Castelli; C Luigiano; M Fadda; M Rizzetto
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  28     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  469-73     Citation Subset:  IM    
Gastro-Hepatology Unit, S. Giovanni Battista (Molinette) Hospital, Turin, Italy.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Biological Markers / blood
Blood Pressure
Body Mass Index
Breath Tests
C-Reactive Protein / metabolism
Cardiovascular Diseases / blood,  etiology*,  physiopathology
Cholesterol, HDL / blood
Fibrinogen / metabolism
Helicobacter Infections / complications,  diagnosis,  drug therapy*,  microbiology
Helicobacter pylori / pathogenicity*
Middle Aged
Remission Induction
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Biological Markers; 0/Cholesterol, HDL; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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