Document Detail

Clinical biochemical and haemodynamic correlates of sodium sensitivity in essential hypertension.
MedLine Citation:
PMID:  6400114     Owner:  NLM     Status:  MEDLINE    
Factors contributing to the blood pressure (BP) response to changes in dietary sodium intake were studied in 25 patients with essential hypertension (EH). Relevant clinical, biochemical and haemodynamic variables were measured after two weeks on a low sodium diet (LS, 50 mmol) and after two weeks on a high sodium diet (HS, 300 mmol). BP was significantly higher during HS. The difference in mean arterial pressure between HS and LS (delta MAP) was taken as a measure of sodium sensitivity. delta MAP was directly related to age, initial BP, plasma noradrenaline during HS and changes in forearm vascular resistance. It was indirectly related to plasma aldosterone during LS. No correlation was found with renin or with the excretion of urinary kallikrein. It is concluded that sodium sensitivity in EH is related to age and blood pressure and is predominantly mediated by changes in vascular resistance to which aldosterone and adrenergic mechanisms are likely to contribute.
M I Koolen; E Bussemaker-Verduyn den Boer; P van Brummelen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  1     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1986-02-18     Completed Date:  1986-02-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  21-3     Citation Subset:  IM    
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MeSH Terms
Aldosterone / blood
Blood Pressure / drug effects*
Clinical Trials as Topic
Diet, Sodium-Restricted*
Heart Rate / drug effects
Hypertension / physiopathology*
Kallikreins / urine
Middle Aged
Muscles / blood supply
Norepinephrine / blood
Random Allocation
Regional Blood Flow / drug effects
Renin / blood
Sodium / pharmacology*,  urine
Vascular Resistance / drug effects
Reg. No./Substance:
51-41-2/Norepinephrine; 52-39-1/Aldosterone; 7440-23-5/Sodium; EC 3.4.21.-/Kallikreins; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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