| Clinical biochemical and haemodynamic correlates of sodium sensitivity in essential hypertension. | |
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MedLine Citation:
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PMID: 6400114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factors contributing to the blood pressure (BP) response to changes in dietary sodium intake were studied in 25 patients with essential hypertension (EH). Relevant clinical, biochemical and haemodynamic variables were measured after two weeks on a low sodium diet (LS, 50 mmol) and after two weeks on a high sodium diet (HS, 300 mmol). BP was significantly higher during HS. The difference in mean arterial pressure between HS and LS (delta MAP) was taken as a measure of sodium sensitivity. delta MAP was directly related to age, initial BP, plasma noradrenaline during HS and changes in forearm vascular resistance. It was indirectly related to plasma aldosterone during LS. No correlation was found with renin or with the excretion of urinary kallikrein. It is concluded that sodium sensitivity in EH is related to age and blood pressure and is predominantly mediated by changes in vascular resistance to which aldosterone and adrenergic mechanisms are likely to contribute. |
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Authors:
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M I Koolen; E Bussemaker-Verduyn den Boer; P van Brummelen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 1 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1986-02-18 Completed Date: 1986-02-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 21-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Blood Pressure / drug effects* Clinical Trials as Topic Diet, Sodium-Restricted* Female Forearm Heart Rate / drug effects Humans Hypertension / physiopathology* Kallikreins / urine Male Middle Aged Muscles / blood supply Norepinephrine / blood Random Allocation Regional Blood Flow / drug effects Renin / blood Sodium / pharmacology*, urine Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 52-39-1/Aldosterone; 7440-23-5/Sodium; EC 3.4.21.-/Kallikreins; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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