| Clinical and biochemical evaluation of chitosan for hypercholesterolemia and overweight control. | |
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MedLine Citation:
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PMID: 10906968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After providing basic information on enzymes involved in cholesterol homeostasis, and on management of hypertriglyceremia and hypercholesterolemia, with the aid of cholestyramine and fibric acid, this chapter examines the effects of the ingestion of chitosan. Dietary chitosan is effective on serum cholesterol and in atherosclerosis in normal and diabetic mice, and lends itself to the treatment of hypercholesterolemia in humans. It also exhibits antiulcer, antiarthritic, antihypertension and antiuricemic properties. The published human trials, analysed statistically, further indicate that chitosan is effective to control overweight when associated to a diet. This chapter discusses several issues raised against the use of chitosan, namely, depletion of zinc and liposoluble vitamins, as well as advantages such as enhanced absorption of nutrients and competitive inhibition of lipases. It also directs attention to the unexplored areas of fungal and algal chitosans, and the use of chitins instead of chitosans. |
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Authors:
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R A Muzzarelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: EXS Volume: 87 ISSN: 1023-294X ISO Abbreviation: EXS Publication Date: 1999 |
Date Detail:
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Created Date: 2000-08-16 Completed Date: 2000-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204529 Medline TA: EXS Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 293-304 Citation Subset: IM |
Affiliation:
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Center for Innovative Biomaterials, University of Ancona, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / therapeutic use* Appetite Depressants / therapeutic use* Chitin / analogs & derivatives*, therapeutic use Chitosan Humans Hypercholesterolemia / drug therapy* Intestinal Absorption / drug effects Mice Obesity / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Appetite Depressants; 1398-61-4/Chitin; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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