| Clinical and biochemical characteristics of normotensive patients with primary aldosteronism: a comparison with hypertensive cases. | |
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MedLine Citation:
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PMID: 18284637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: It is unknown why some patients with biochemical evidence of primary aldosteronism (PA) do not develop hypertension. We aimed to compare clinical and biochemical characteristics of normotensive and hypertensive patients with PA. DESIGN AND PATIENTS: Retrospective comparison of 10 normotensive and 168 hypertensive patients with PA for office or ambulatory blood pressure, serum potassium, plasma aldosterone and renin concentrations; the aldosterone:renin ratio, and tumour size. Comparison of initial hormonal pattern and drop in blood pressure following adrenalectomy in five normotensive and nine hypertensive patients matched for age, sex and body mass index. RESULTS: The 10 normotensive patients were women and presented with hypokalemia or an adrenal mass. Age, plasma aldosterone and renin concentrations were similar in normotensive and hypertensive cases, but kalemia and body mass index were significantly lower in the normotensive patients. Mean tumour diameter was larger in the normotensive patients than in the hypertensive matched patients with an adenoma (P < 0.01). In normotensive patients, diastolic blood pressure and upright aldosterone correlated negatively with kalemia. Blood pressure was lowered similarly after adrenalectomy in five normotensive PA patients and in their matched hypertensive counterparts. Aldosterone synthase expression was detected in four out of five adrenal tumours. CONCLUSIONS: Blood pressure may be normal in patients with well-documented PA. The occurrence of hypokalemia, despite a normal blood pressure profile, suggests that protective mechanisms against hypertension are present in normotensive patients. |
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Authors:
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Virginie Médeau; François Moreau; Ludovic Trinquart; Maud Clemessy; Jean-Louis Wémeau; Marie Christine Vantyghem; Pierre-François Plouin; Yves Reznik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-01 |
Journal Detail:
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Title: Clinical endocrinology Volume: 69 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-07 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 20-8 Citation Subset: IM |
Affiliation:
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Département d'Hypertension, AP-HP, Hôpital Européen Georges Pompidou, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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complications,
genetics,
metabolism Adrenalectomy Adrenocortical Adenoma / complications, genetics, metabolism Adult Aldosterone Synthase / genetics, metabolism Biological Markers / analysis*, metabolism Blood Pressure / physiology* Case-Control Studies Female Follow-Up Studies Humans Hyperaldosteronism / complications, etiology, genetics, physiopathology* Hypertension / complications*, genetics, metabolism Male Middle Aged Retrospective Studies Steroid 11-beta-Hydroxylase / genetics, metabolism Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; EC 1.14.15.4/Aldosterone Synthase; EC 1.14.15.4/Steroid 11-beta-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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