| Clinical benefit of cardiac ischemic postconditioning in corrections of tetralogy of Fallot. | |
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MedLine Citation:
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PMID: 18854339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The postoperative course of cyanotic patients is generally more complicated than in acyanotic patients. The ischemic postconditioning provides protection from myocardial injury. We conducted a randomized trial to evaluate the clinical benefits of postconditioning in patients undergoing repair of tetralogy of Fallot. Ninety-nine patients with tetralogy of Fallot were randomly assigned to ischemic postconditioning group (n=48) or control group (n=51). The postconditioning was performed by intermittent aortic clamping after reperfusion. The morbidity, mortality, ventilation time, length of ICU stay, inotropic score, release of troponin I and lactate were assayed. There was one death in postconditioned group and two in control. Major non-fatal morbidity was reduced in postconditioned patients (12.5%, 6/48) compared with control (33.3%, 17/51, P=0.016). The troponin I was significantly lower (P=0.026) with reduced inotrope score (P=0.001) and lactate release (P=0.019) in postconditioned patients. The ventilation time was significantly reduced in postconditioned patients compared with control (14+/-15 h vs. 25+/-28 h, P=0.024). There was a significant decrease in the ICU stay in the postconditioned patients (P=0.048). The study suggests that ischemic postconditioning may provide clinical benefits with respect to the morbidity, ventilation time, ICU stay, requirement of inotrope in patients undergoing repair for tetralogy of Fallot. |
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Authors:
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Bei Li; Ri Chen; Rimao Huang; Wanjun Luo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-10-14 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 8 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-05 Completed Date: 2009-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 17-21 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, Xiang Ya Hospital, Central South University, Changsha, Hunan, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aorta / surgery* Cardiac Surgical Procedures* / adverse effects, mortality Cardiotonic Agents / therapeutic use Child Child, Preschool Constriction Female Humans Intensive Care Units Lactic Acid / blood Length of Stay Male Myocardial Contraction / drug effects Myocardial Reperfusion Injury / etiology, mortality, physiopathology, prevention & control* Reperfusion / methods* Respiration, Artificial Tetralogy of Fallot / mortality, physiopathology, surgery* Treatment Outcome Troponin I / blood |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Troponin I; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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