Document Detail

Clinical benefit of cardiac ischemic postconditioning in corrections of tetralogy of Fallot.
MedLine Citation:
PMID:  18854339     Owner:  NLM     Status:  MEDLINE    
The postoperative course of cyanotic patients is generally more complicated than in acyanotic patients. The ischemic postconditioning provides protection from myocardial injury. We conducted a randomized trial to evaluate the clinical benefits of postconditioning in patients undergoing repair of tetralogy of Fallot. Ninety-nine patients with tetralogy of Fallot were randomly assigned to ischemic postconditioning group (n=48) or control group (n=51). The postconditioning was performed by intermittent aortic clamping after reperfusion. The morbidity, mortality, ventilation time, length of ICU stay, inotropic score, release of troponin I and lactate were assayed. There was one death in postconditioned group and two in control. Major non-fatal morbidity was reduced in postconditioned patients (12.5%, 6/48) compared with control (33.3%, 17/51, P=0.016). The troponin I was significantly lower (P=0.026) with reduced inotrope score (P=0.001) and lactate release (P=0.019) in postconditioned patients. The ventilation time was significantly reduced in postconditioned patients compared with control (14+/-15 h vs. 25+/-28 h, P=0.024). There was a significant decrease in the ICU stay in the postconditioned patients (P=0.048). The study suggests that ischemic postconditioning may provide clinical benefits with respect to the morbidity, ventilation time, ICU stay, requirement of inotrope in patients undergoing repair for tetralogy of Fallot.
Bei Li; Ri Chen; Rimao Huang; Wanjun Luo
Related Documents :
22580619 - Optical coherence tomography for biofilm detection in chronic rhinosinusitis with nasal...
2875609 - Respiratory irregularity and tardive dyskinesia. a prevalence study.
8480589 - The safety of transesophageal echocardiography in the elderly.
19770169 - Body mass index is associated with the development of acute respiratory distress syndrome.
22706739 - Investigation into bacteremia and spontaneous bacterial peritonitis in patients with li...
7599839 - Serum surfactant protein-a levels in patients with acute cardiogenic pulmonary edema an...
1939699 - Intellectual loss in alzheimer's dementia and wais-r intrasubtest scatter.
10155229 - Cardiopulmonary bypass support of high risk coronary angioplasty patients: registry res...
14755139 - Clinical patterns of diffuse parenchymal lung disease in kuwait: a prospective study.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-10-14
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  8     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Xiang Ya Hospital, Central South University, Changsha, Hunan, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta / surgery*
Cardiac Surgical Procedures* / adverse effects,  mortality
Cardiotonic Agents / therapeutic use
Child, Preschool
Intensive Care Units
Lactic Acid / blood
Length of Stay
Myocardial Contraction / drug effects
Myocardial Reperfusion Injury / etiology,  mortality,  physiopathology,  prevention & control*
Reperfusion / methods*
Respiration, Artificial
Tetralogy of Fallot / mortality,  physiopathology,  surgery*
Treatment Outcome
Troponin I / blood
Reg. No./Substance:
0/Cardiotonic Agents; 0/Troponin I; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surgical strategies for organ malperfusions in acute type B aortic dissection.
Next Document:  Screening for deep vein thrombosis in asymptomatic high-risk patients: a comparison between digital ...