| Clinical assessment of positron emission tomography for the diagnosis of local recurrence in colorectal cancer. | |
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MedLine Citation:
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PMID: 10417568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The clinical value of positron emission tomography (PET) for the diagnosis of local pelvic recurrence of colorectal cancer was evaluated. METHODS: Computed tomography (CT) and magnetic resonance imaging (MRI) of the pelvis were performed at regular intervals in 23 patients who had undergone resection for colorectal cancer. The 23 patients had a total of 25 lesions. PET images of the 25 lesions and of six primary lesions in patients with rectal cancer were obtained. A differential absorption ratio (DAR) was calculated in order to examine the accumulation of [18F]2-fluoro-2-deoxy-D-glucose (18FDG) on PET images. Histological diagnoses of the pelvic masses were obtained by CT-guided needle biopsy. RESULTS: On CT or MRI, a pelvic mass with a spicular shape (n = 1) was non-recurrent, whereas a nodular or lumpy shape indicated a locally recurrent lesion (n = 10). Masses with a nodulospicular shape (n = 12) did not correlate with the histological features. On PET, 15 of 16 histologically proven local recurrences were imaged positively. By setting a DAR of 2.8 as a cut-off value, local recurrences could be diagnosed with 100 per cent accuracy. CONCLUSION: PET is a clinically useful tool for the detection of local recurrence of colorectal cancer, particularly for distinguishing between recurrence and granulation tissues in the pelvic cavity. |
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Authors:
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O Takeuchi; N Saito; K Koda; H Sarashina; N Nakajima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of surgery Volume: 86 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-01 Completed Date: 1999-09-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 932-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Kimitsu chuo Hospital, Sakurai, Kisarazu, Chiba, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Colorectal Neoplasms / radionuclide imaging* Humans Magnetic Resonance Imaging Middle Aged Neoplasm Recurrence, Local / radionuclide imaging* Tomography, Emission-Computed* |
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