Document Detail


Clinical assessment and management of the endometrium in recurrent early pregnancy loss.
MedLine Citation:
PMID:  22161462     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Unexplained and recurrent loss of pregnancies is a heartbreaking and frustrating condition. The routine diagnostic workup for pregnancy loss includes hormonal evaluation, screening for genetic or chromosomal defects, immunologic and thrombophilic testing, and evaluation of congenital or acquired Müllerian defects. In cases of idiopathic pregnancy loss, defects in endometrial receptivity are increasingly being investigated. The role of the endometrium in pregnancy loss has historical roots but remains controversial. Exciting new directions based on microRNAs, proteomics, and epigenetics promises to keep this area of investigation both interesting and complex. With each new diagnostic and therapeutic biomarker identified comes a greater potential for diagnosis and treatment of women. The clinical assessment of the endometrium remains an important part of the investigation of couples with unexplained pregnancy loss.
Authors:
Bansari G Patel; Bruce A Lessey
Publication Detail:
Type:  Journal Article     Date:  2011-12-08
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  29     ISSN:  1526-4564     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  491-506     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Affiliation:
Department of Obstetrics and Gynecology, Greenville, South Carolina.
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