| Clinical assessment and management of the endometrium in recurrent early pregnancy loss. | |
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MedLine Citation:
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PMID: 22161462 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Unexplained and recurrent loss of pregnancies is a heartbreaking and frustrating condition. The routine diagnostic workup for pregnancy loss includes hormonal evaluation, screening for genetic or chromosomal defects, immunologic and thrombophilic testing, and evaluation of congenital or acquired Müllerian defects. In cases of idiopathic pregnancy loss, defects in endometrial receptivity are increasingly being investigated. The role of the endometrium in pregnancy loss has historical roots but remains controversial. Exciting new directions based on microRNAs, proteomics, and epigenetics promises to keep this area of investigation both interesting and complex. With each new diagnostic and therapeutic biomarker identified comes a greater potential for diagnosis and treatment of women. The clinical assessment of the endometrium remains an important part of the investigation of couples with unexplained pregnancy loss. |
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Authors:
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Bansari G Patel; Bruce A Lessey |
Publication Detail:
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Type: Journal Article Date: 2011-12-08 |
Journal Detail:
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Title: Seminars in reproductive medicine Volume: 29 ISSN: 1526-4564 ISO Abbreviation: Semin. Reprod. Med. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909394 Medline TA: Semin Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 491-506 Citation Subset: IM |
Copyright Information:
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© Thieme Medical Publishers. |
Affiliation:
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Department of Obstetrics and Gynecology, Greenville, South Carolina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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