Document Detail

Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome.
MedLine Citation:
PMID:  18460953     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Early identification of acute coronary syndrome (ACS) in the emergency room is still a difficult task. The objective of this study is to estimate the reliability of heart-type fatty acid binding protein (H-FABP) in identifying ACS in the early stage of chest pain onset. METHODS: In a prospective multicentre study in emergency room patients with suspected ACS lasting less than 3 h, heart heart-type fatty acid binding protein (H-FABP) was compared with conventional biomarkers. Protein levels >7 ng/ml were considered positive results. RESULTS: A total of 419 patients were analyzed. Acute myocardial infarction was diagnosed in 148 patients (35%). H-FABP sensitivity was 60% (89 out of 148 patients), significantly higher than troponin T [19% (28 out of 148 patients); P<0,05]. Specificity of troponin T, however, [99% (270 out of 271 patients)] was better than H-FABP [88% (237 out of 271 patients)], though this was not statistically significant. CONCLUSION: H-FABP can be a useful early diagnostic biochemical marker, particularly within the first 6 h of symptoms, in patients attending the emergency department.
Hector Alonso Valle; Luis García-Castrillo Riesgo; Miguel Sántalo Bel; Francisco Epelde Gonzalo; Miguel Sánchez Sanchez; Luis Iglesias Oliva
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  European journal of emergency medicine : official journal of the European Society for Emergency Medicine     Volume:  15     ISSN:  1473-5695     ISO Abbreviation:  Eur J Emerg Med     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442482     Medline TA:  Eur J Emerg Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  140-4     Citation Subset:  IM    
Emergency Department, Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain.
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MeSH Terms
Acute Coronary Syndrome / blood,  diagnosis*
Biological Markers / blood
Chest Pain / etiology
Emergency Service, Hospital
Fatty Acid-Binding Proteins / blood*
Middle Aged
Myocardial Infarction / blood,  diagnosis*
Prospective Studies
Sensitivity and Specificity
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Troponin T

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