Document Detail

Clinical aspects of food allergy.
MedLine Citation:
PMID:  12440942     Owner:  NLM     Status:  MEDLINE    
Food allergy affects 2.5% of adults and 6-8% of children, and is a leading cause of life-threatening anaphylactic episodes. Food allergy is defined as an adverse reaction to foods that is mediated immunologically and involves specific IgE or non-IgE mechanisms. In this review only IgE-related food allergy will be considered. Many food allergens are glycoproteins, but they do not share any striking biochemical similarities. The definition of many food proteins at the molecular level has tremendously facilitated our understanding of clinical syndromes and seemingly bizarre observations. Clinical manifestations of food allergy include symptoms of the gastrointestinal, cutaneous and respiratory systems, as well as systemic anaphylaxis. The diagnosis of food allergy involves a stepwise approach, including medical history taking, demonstration of specific IgE and confirmation by oral food challenge. The management of the food-allergic patient at present consists of avoidance of the culprit food and education, while future advances may include specific immunotherapy with modified allergens or DNA vaccination.
P S Papageorgiou
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  30     ISSN:  0300-5127     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-20     Completed Date:  2003-06-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  901-6     Citation Subset:  IM    
Athens University School of Medicine, P & A. Kyriakou Children's Hospital, Allergy Unit, Greece 115 27.
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MeSH Terms
Food Hypersensitivity / diagnosis*,  etiology
Immunoglobulin E / immunology*
Intradermal Tests
Skin / immunology
Reg. No./Substance:
37341-29-0/Immunoglobulin E

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