Document Detail


Clinical aspects and distribution of immunologically active cells in the nasal mucosa of patients with nasal polyps after endoscopic sinus surgery and treatment with topical corticosteroids.
MedLine Citation:
PMID:  1358129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical parameters of 72 patients who were operated upon for nasal polyps were evaluated as well as biopsy specimens of the mucosa of the middle and inferior turbinates of 41 of these patients. Biopsies were taken at the time of endoscopic sinus surgery (ESS), after 6 months and after 1 year in 23 patients. During the follow-up period the patients were treated with topical corticosteroids (budesonide). At the time of ESS significantly more CD8+ (suppressor/cytotoxic) cells than CD4+ (helper/inducer) cells were found in the middle and inferior turbinates. At 6 months significantly more CD4+ cells were found than at the time of ESS, whereas at 1 year the number of CD4+ cells had decreased and was lower than at 6 months. These data support the theory that the occurrence of nasal polyps is associated with T-cell-dependent disturbances. Clinical evaluation revealed that most of the patients with chronic airway obstruction had better pulmonary functions postoperatively or required less medication for lung disease. These findings show that ESS combined with topical corticosteroids has a positive effect on upper and lower respiratory tract pathology.
Authors:
A E Stoop; H A van der Heijden; J Biewenga; S van der Baan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  249     ISSN:  0937-4477     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  313-7     Citation Subset:  IM; X    
Affiliation:
Department of Otorhinolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adolescent
Adult
Aged
Anti-Inflammatory Agents / therapeutic use*
Antigens, CD / analysis
Antigens, CD2
Antigens, CD22
Antigens, Differentiation, B-Lymphocyte / analysis
Antigens, Differentiation, T-Lymphocyte / analysis
Budesonide
CD4-CD8 Ratio
Cell Adhesion Molecules*
Combined Modality Therapy
Endoscopy*
Glucocorticoids
Humans
Lectins*
Lymphocytes / immunology*,  pathology*
Middle Aged
Nasal Mucosa / immunology*,  pathology
Nasal Polyps / drug therapy,  immunology*,  pathology,  surgery*
Pregnenediones / administration & dosage*
Receptors, Immunologic / analysis
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antigens, CD; 0/Antigens, CD2; 0/Antigens, CD22; 0/Antigens, Differentiation, B-Lymphocyte; 0/Antigens, Differentiation, T-Lymphocyte; 0/CD22 protein, human; 0/Cell Adhesion Molecules; 0/Glucocorticoids; 0/Lectins; 0/Pregnenediones; 0/Receptors, Immunologic; 51333-22-3/Budesonide

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