Document Detail

Clinical aspects of coenzyme Q10: an update.
MedLine Citation:
PMID:  19932599     Owner:  NLM     Status:  MEDLINE    
The fundamental role of coenzyme Q(10) (CoQ(10)) in mitochondrial bioenergetics and its well-acknowledged antioxidant properties constitute the basis for its clinical applications, although some of its effects may be related to a gene induction mechanism. Cardiovascular disease is still the main field of study and the latest findings confirm a role of CoQ(10) in improving endothelial function. The possible relation between CoQ(10) deficiency and statin side effects is highly debated, particularly the key issue of whether CoQ(10) supplementation counteracts statin myalgias. Furthermore, in cardiac patients, plasma CoQ(10) was found to be an independent predictor of mortality. Studies on CoQ(10) and physical exercise have confirmed its effect in improving subjective fatigue sensation and physical performance and in opposing exercise-related damage. In the field of mitochondrial myopathies, primary CoQ(10) deficiencies have been identified, involving different genes of the CoQ(10) biosynthetic pathway; some of these conditions were found to be highly responsive to CoQ(10) administration. The initial observations of CoQ(10) effects in Parkinson's and Huntington's diseases have been extended to Friedreich's ataxia, where CoQ(10) and other quinones have been tested. CoQ(10) is presently being used in a large phase III trial in Parkinson's disease. CoQ(10) has been found to improve sperm count and motility on asthenozoospermia. Moreover, for the first time CoQ(10) was found to decrease the incidence of preeclampsia in pregnancy. The ability of CoQ(10) to mitigate headache symptoms in adults was also verified in pediatric and adolescent populations.
Gian Paolo Littarru; Luca Tiano
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-11-22
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  26     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  250-4     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy.
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MeSH Terms
Cardiovascular Diseases / metabolism
Energy Metabolism
Exercise / physiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
Ubiquinone / analogs & derivatives*,  pharmacology,  therapeutic use
Vitamins / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Vitamins; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

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