| Clinical aspects of antenatal glucocorticoid treatment for prevention of neonatal respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 3443899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Main indications for antenatal administration glucocorticoid to pregnant women are premature contractions, hemorrhage during pregnancy, conditions of fetal distress and maternal diseases. There are some absolute or relative contraindications as well: severe forms of preeclampsia, diabetes mellitus, premature rupture of membranes, maternal and/intrauterine infections. In a retrospective evaluation of the data obtained at our institution of 637 nonrandomized cases from the years 1980-1985, we could demonstrate the dependence of the therapeutic results on the sex of the newborn. The RDS incidence is significantly different after betamethasone prophylaxis. It was 1/25 (4%) in girls compared to 13/31 (42%) in boys. A marked reduction of the RDS incidence is only detectable after betamethasone therapy from the 32nd to the 34th week of gestation. Thus we recommend RDS prophylaxis for all patients with premature contraction, mainly between the 32nd and 34th week of pregnancy. In addition, it should be given in cases of confirmed lung immaturity. Special restrictions are necessary in cases of preeclampsia, eclampsia, diabetes and confirmed maternal infections. In the group of diabetes or preeclampsia patients an RDS prophylaxis should only be given, if at all, when it can be performed under intensive care conditions. |
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Authors:
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H K Weitzel; U Lorenz; B Kipper |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 15 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 1987 |
Date Detail:
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Created Date: 1988-05-06 Completed Date: 1988-05-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Affiliation:
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Department for Obstetrics and Gynecology, Free University of Berlin, West Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Betamethasone
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therapeutic use* Dexamethasone / therapeutic use* Embryonic and Fetal Development / drug effects Female Humans Infant, Newborn Lung / drug effects, embryology* Male Respiratory Distress Syndrome, Newborn / prevention & control* |
| Chemical | |
Reg. No./Substance:
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378-44-9/Betamethasone; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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