Document Detail

Clinical aspects of 100 patients with Kawasaki disease.
MedLine Citation:
PMID:  1900405     Owner:  NLM     Status:  MEDLINE    
We report 101 episodes of Kawasaki disease in 100 patients seen over a 12 year period. A total of 35 patients had cardiac involvement ranging from pericardial effusion to coronary artery aneurysms with ischaemic complications, which resulted in death in one patient. Laboratory investigations showed leucocytosis, thrombocytosis, and a raised erythrocyte sedimentation rate to be common features and the first two variables were significantly associated with cardiac involvement. Treatment regimens changed over the study period. Aspirin was used in most patients often in conjunction with dipyridamole and from 1986 intravenous immunoglobulin was given routinely to those patients seen early in the illness. Additional therapeutic measures in individual patients included prostacyclin, heparin, streptokinase, and plasma exchange/exchange transfusion. Attention is drawn to the uncertainity of the long term cardiovascular consequences in the light of adults reported with premature atherosclerotic lesions of similar appearance to those seen in Kawasaki disease.
E J Tizard; A Suzuki; M Levin; M J Dillon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  66     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-04-10     Completed Date:  1991-04-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  AIM; IM    
Department of General Paediatrics and Nephrology, Hospital for Sick Children, London.
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MeSH Terms
Aspirin / therapeutic use
Blood Sedimentation
Child, Preschool
Coronary Aneurysm / blood,  etiology
Coronary Disease / blood,  etiology
Dipyridamole / therapeutic use
Immunoglobulin G / therapeutic use
Immunoglobulins, Intravenous
Leukocyte Count
Mucocutaneous Lymph Node Syndrome / blood,  drug therapy,  immunology,  pathology*
Platelet Count
Retrospective Studies
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulins, Intravenous; 50-78-2/Aspirin; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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