| Clinical approach to lupus nephritis: recent advances. | |
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MedLine Citation:
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PMID: 19712841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kidney involvement is common in systemic lupus erythematosus (SLE). Its clinical presentations are highly variable, ranging from mild asymptomatic proteinuria and/or hematuria to rapidly progressive uremia. Histological evidence of lupus nephritis is present in most patients with SLE, even when they do not yet have clinical manifestations. Current classification ISN/RPS 2003 (International Society of Nephrology/Renal Pathology Society) of lupus nephritis was promoted by a widely perceived need to re-examine existing classification, provide clearer distinctions between the histological classes, and improve diagnostic reproducibility and interobserver agreement. Lupus nephritis is a serious disease whose prognosis can usually be improved dramatically by treatment, but treatment is potentially toxic, prolonged, and complex. Current treatment regimens combine corticosteroids with cyclophosphamide, azathioprine or ciclosporin; mycophenolate mofetil has received much recent attention as a potentially immune suppressive agent and less aggressive immunosuppressive regimens can be prescribed. SLE patients should be regular followed to detect early kidney involvement. |
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Authors:
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C Molino; F Fabbian; C Longhini |
Publication Detail:
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Type: Journal Article; Review Date: 2009-02-04 |
Journal Detail:
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Title: European journal of internal medicine Volume: 20 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-28 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 447-53 Citation Subset: IM |
Copyright Information:
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2008 European Federation of Internal Medicine. |
Affiliation:
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Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy. clinicamedica@unife.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Antiphospholipid Syndrome / etiology Humans Immunosuppressive Agents / therapeutic use Lupus Nephritis / complications, diagnosis*, therapy* Prognosis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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