Document Detail

Clinical approach to intestinal maturation in neonates prenatally exposed to alcohol.
MedLine Citation:
PMID:  17341514     Owner:  NLM     Status:  MEDLINE    
AIM: The need for a non-invasive diagnosis of the effects of ethanol in utero on the development of the intestine in humans led us to look for a serum marker of the structural integrity of the intestine. We propose apolipoprotein A-IV (apoA-IV) as a possible candidate. In humans this protein is synthesized only by intestinal mucosa, it is expressed in the enterocyte of the foetus from 20 weeks of gestation, and it is released to the blood stream after synthesis. METHODS: We measured the levels of apoA-IV in the umbilical cord serum of neonates whose mothers had consumed alcohol during pregnancy and neonates born to women who had not (controls). The gestational age at delivery of the cases studied ranged from 36 to 42 weeks. ELISA and Western blot analysis were used. RESULTS: There was no difference in the mean body weight of neonates from either group. Nevertheless, exposure to ethanol in utero significantly reduced (by about 30%) the apoA-IV levels in serum at birth, regardless of body weight. CONCLUSION: Our findings suggest that circulating apoA-IV levels could be used as a clinical marker of the prenatal effects of ethanol on the structural integrity of the intestine. Neonatal diagnosis of these intestinal effects could improve post-natal outcome.
Carmen Través; Oriol Coll; Vicens Cararach; Antoni Gual; Begoña Martínez de Tejada; M Dolores López-Tejero
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Publication Detail:
Type:  Journal Article     Date:  2007-03-06
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  42     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-10-15     Completed Date:  2008-01-02     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  England    
Other Details:
Languages:  eng     Pagination:  407-12     Citation Subset:  IM    
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Av/ Diagonal 645, Barcelona, Spain.
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MeSH Terms
Apolipoprotein E4 / blood
Biological Markers / blood
Birth Weight / drug effects
Blotting, Western
Cholesterol / blood
Enzyme-Linked Immunosorbent Assay
Fetal Alcohol Syndrome / pathology*
Fetal Blood / chemistry
Infant, Newborn
Intestinal Mucosa / cytology,  growth & development,  pathology
Intestines / drug effects,  growth & development*,  pathology
Prospective Studies
Reg. No./Substance:
0/Apolipoprotein E4; 0/Biological Markers; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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