Document Detail


Clinical applications of miRNAs in cardiac remodeling and heart failure.
MedLine Citation:
PMID:  21399714     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
MicroRNAs (miRNAs or miRs) are short, highly conserved noncoding RNAs that regulate gene expression at the post-transcriptional level by inhibiting translation or promoting the degradation of target mRNA. Even though the field of miRNA biology is relatively young, growing lines of evidence suggest that miRNAs play a key role pathogenesis of heart failure through their ability to regulate genes that govern the process of adaptive and maladaptive cardiac remodeling. Herein, we review the biology of miRNAs in relation to their role in modulating various aspects of the cardiac remodeling process, as well as discuss the potential applications of miRNA biology to the field of heart failure.
Authors:
Veli K Topkara; Douglas L Mann
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Personalized medicine     Volume:  7     ISSN:  1741-0541     ISO Abbreviation:  -     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2011-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101238549     Medline TA:  Per Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  531-548     Citation Subset:  -    
Affiliation:
Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL058081-07//NHLBI NIH HHS; R01 HL089543-02//NHLBI NIH HHS

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