| Clinical applications of genomics in head and neck cancer. | |
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MedLine Citation:
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PMID: 16284976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Advances in gene expression analyses have allowed global assessment of expressed genes in clinical samples. Gene expression profiles derived from clinical specimens have been used to distinguish differences in tumors that are not obvoius by clinical, radiographic, or histologic characteristics. Despite its common histology and presentation, head and neck squamous cell carcinoma (HNSCC) is associated with widely varying clinical behavior and response to therapy. Currently, clinicians have a dearth of tools to predict response to therapy or to identify patients at high risk of poor outcome. Recently comprehensive analyses of gene expression patterns of individual tumors have shown promise to improve discovery of biomarkers for 1) progression of premalignant lesions, 2) disease presence or absence, 3) prediction of clinical outcome, and 4) identification of targets for therapy. In this review, we will discuss advances, limitations and future directions of genomics as it applies to HNSCC. |
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Authors:
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Christine H Chung; Shawn Levy; Wendell G Yarbrough |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Head & neck Volume: 28 ISSN: 1043-3074 ISO Abbreviation: Head Neck Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-27 Completed Date: 2006-09-12 Revised Date: 2006-10-05 |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 360-8 Citation Subset: IM |
Copyright Information:
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Copyright 2005 Wiley Periodicals, Inc. |
Affiliation:
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Division of Hematology/Oncology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2559, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Genomics* Head and Neck Neoplasms / genetics*, prevention & control Humans Neoplasm Metastasis / genetics, prevention & control Neoplasm Recurrence, Local / pathology Neoplasm Staging / methods Oligonucleotide Array Sequence Analysis Precancerous Conditions / genetics Survival Analysis |
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