| Clinical application of pharmacokinetic analysis as a biomarker of solitary pulmonary nodules: Dynamic contrast-enhanced MR imaging. | |
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MedLine Citation:
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PMID: 22231729 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study is to evaluate perfusion indices and pharmacokinetic parameters in solitary pulmonary nodules (SPNs). Thirty patients of 34 enrolled with SPNs (15-30 mm) were evaluated in this study. T1 and T2-weighted structural images and 2D turbo FLASH perfusion images were acquired with shallow free breathing. B-spline nonrigid image registration and optimization by χ(2) test against pharmacokinetic model curve were performed on dynamic contrast-enhanced MRI. This allowed voxel-by-voxel calculation of k(ep) , the rate constant for tracer transport to and from plasma and the extravascular extracellular space. Mean transit time, time-to-peak, initial slope, and maximum enhancement (E(max) ) were calculated from time-intensity curves fitted to a gamma variate function. After blinded data analysis, correlation with tissue histology from surgical resection or biopsy samples was performed. Histologic evaluation revealed 25 malignant and five benign SPNs. All benign SPNs had k(ep) < 1.0 min(-1) . Nineteen of 25 (76%) malignant SPNs showed k(ep) > 1.0 min(-1) . Sensitivity to diagnose malignant SPNs at a cutoff of k(ep) = 1.0 min(-1) was 76%, specificity was 100%, positive predictive value was 100%, negative predictive value was 45%, and accuracy was 80%. Of all indices studied, k(ep) was the most significant in differentiating malignant from benign SPNs. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Hatsuho Mamata; Junichi Tokuda; Ritu R Gill; Robert F Padera; Robert E Lenkinski; David J Sugarbaker; James P Butler; Hiroto Hatabu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. hatsuho@bwh.harvard.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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