Document Detail

Clinical application of mild therapeutic hypothermia after cardiac arrest.
MedLine Citation:
PMID:  17334257     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Postresuscitative mild hypothermia lowers mortality, reduces neurologic impairment after cardiac arrest, and is recommended by the International Liaison Committee on Resuscitation. The European Resuscitation Council Hypothermia After Cardiac Arrest Registry was founded to monitor implementation of therapeutic hypothermia, to observe feasibility of adherence to the guidelines, and to document the effects of hypothermic treatment in terms of complications and outcome. DESIGN: Cardiac arrest protocols, according to Utstein style, with additional protocols on cooling and rewarming procedures and possible adverse events are documented. SETTING: Between March 2003 and June 2005, data on 650 patients from 19 sites within Europe were entered. PATIENTS: Patients who had cardiac arrest with successful restoration of spontaneous circulation were studied. MEASUREMENTS AND MAIN RESULTS: Of all patients, 462 (79%) received therapeutic hypothermia, 347 (59%) were cooled with an endovascular device, and 114 (19%) received other cooling methods such as ice packs, cooling blankets, and cold fluids. The median cooling rate was 1.1 degrees C per hour. Of all hypothermia patients, 15 (3%) had an episode of hemorrhage and 28 patients (6%) had at least one episode of arrhythmia within 7 days after cooling. There were no fatalities as a result of cooling. CONCLUSIONS: Therapeutic hypothermia is feasible and can be used safely and effectively outside a randomized clinical trial. The rate of adverse events was lower and the cooling rate was faster than in clinical trials published.
Jasmin Arrich;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  35     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-05-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1041-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiopulmonary Resuscitation / methods*
Guideline Adherence
Heart Arrest / mortality,  therapy*
Hospital Mortality
Hypothermia, Induced / adverse effects,  methods*
Intensive Care Units
Middle Aged
Practice Guidelines as Topic
Treatment Outcome
Comment In:
Crit Care Med. 2007 Apr;35(4):1199-202   [PMID:  17413789 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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