Document Detail


Clinical application of the measurement of spontaneous erythrocyte aggregation and disaggregation. A pilot study.
MedLine Citation:
PMID:  9699029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aggregation and disaggregation kinetics of erythrocytes in samples of whole blood were studied using a backscattering nephelometry technique. Blood was drawn from normal subjects and from patients suffering from different diseases: chronic glomerulonephritis, systemic lupus erythematosus, hereditary hypercholesterolemia, pulmonary hypertension, intestinal tumors preoperatively (age > 60 years), psoriasis, psoriatic arthritis, ischemia and ischemia with diabetes. Blood samples of healthy donors were used as controls. The backscattering signal in the erythroaggregometer was processed according to algorithms yielding quantitative data on the full amplitude of aggregation, characteristic times of spontaneous aggregation, average hydrodynamic strength of all aggregates and, whenever possible, additionally, strength of the largest aggregates. The obtained results confirm that the complexity of erythrocyte aggregation kinetics requires multiparametric description which, when applied to clinical material, enables the differentiation of aggregation characteristics between diseases.
Authors:
N N Firsov; A Bjelle; T V Korotaeva; A V Priezzhev; O M Ryaboshapka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  18     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-10     Completed Date:  1998-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  87-97     Citation Subset:  IM    
Affiliation:
Russian State Medical University, Moscow, Russia.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers
Erythrocyte Aggregation*
Humans
Kinetics
Nephelometry and Turbidimetry
Pilot Projects
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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