Document Detail


Clinical application of fetal sex determination using cell-free fetal DNA in pregnant carriers of X-linked genetic disorders.
MedLine Citation:
PMID:  21307866     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
As the first step in prenatal diagnosis of X-linked genetic disorders, chorionic villus sampling (CVS) for fetal sex determination is generally performed at 11-13 weeks of gestation. However, as the procedure-related miscarriage rate of CVS is 0.5-1.0%, non-invasive methods such as PCR of cell-free fetal DNA (cff-DNA) in maternal plasma are preferable. Here, we determined fetal sex at 9-12 weeks of gestation using PCR of cff-DNA in three pregnant carriers of Duchenne muscular dystrophy. The fetal sex was accurately determined in all three cases, as confirmed by ultrasound and amniocentesis at 16 weeks (for the two female fetuses) and CVS at 12 weeks (for the one male fetus). This procedure could avoid unnecessary CVS in female fetuses.Journal of Human Genetics advance online publication, 10 February 2011; doi:10.1038/jhg.2011.7.
Authors:
Kiyonori Miura; Ai Higashijima; Takako Shimada; Shoko Miura; Kentaro Yamasaki; Shuhei Abe; Ozora Jo; Akira Kinoshita; Atsushi Yoshida; Shuichiro Yoshimura; Norio Niikawa; Koh-Ichiro Yoshiura; Hideaki Masuzaki
Related Documents :
25053196 - Influence of threatened miscarriage on pregnancy and early postpartum period: a case-co...
3070536 - Lack of short-term modulation of in vitro placental progesterone secretion in sheep.
21526636 - The incidence, pattern and management outcomes of early pregnancy losses at the ebonyi ...
21518136 - Interstitial pregnancy treated by transcervical aspiration of the gestational sac combi...
6786806 - Sequential fluoroimmunoassay for measurement of pregnancy specific beta 1 glycoprotein ...
10796746 - Laparoscopic "drilling" by diathermy or laser for ovulation induction in anovulatory po...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-10
Journal Detail:
Title:  Journal of human genetics     Volume:  -     ISSN:  1435-232X     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical and molecular genetic analysis in Chinese patients with distal myopathy with rimmed vacuole...
Next Document:  Molecular characterization of phenylketonuria and tetrahydrobiopterin-responsive phenylalanine hydro...