| Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism. | |
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MedLine Citation:
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PMID: 7623069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron emission tomography was used to investigate the metabolism of nucleic acids by 18F-fluoro-2'-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 +/- 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 +/- 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism. |
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Authors:
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M Kameyama; K Ishiwata; Y Tsurumi; J Itoh; K Sato; R Katakura; T Yoshimoto; J Hatazawa; M Ito; T Ido |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of neuro-oncology Volume: 23 ISSN: 0167-594X ISO Abbreviation: J. Neurooncol. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-08-28 Completed Date: 1995-08-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 53-61 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Tohoku University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain Neoplasms / metabolism*, radionuclide imaging* DNA, Neoplasm / metabolism* Female Floxuridine / diagnostic use* Fluorine Radioisotopes / diagnostic use Glioma / metabolism*, radionuclide imaging* Humans Male Middle Aged RNA, Neoplasm / metabolism* Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Fluorine Radioisotopes; 0/RNA, Neoplasm; 50-91-9/Floxuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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