Document Detail


Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism.
MedLine Citation:
PMID:  7623069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positron emission tomography was used to investigate the metabolism of nucleic acids by 18F-fluoro-2'-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 +/- 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 +/- 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.
Authors:
M Kameyama; K Ishiwata; Y Tsurumi; J Itoh; K Sato; R Katakura; T Yoshimoto; J Hatazawa; M Ito; T Ido
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  23     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-28     Completed Date:  1995-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  53-61     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Tohoku University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Neoplasms / metabolism*,  radionuclide imaging*
DNA, Neoplasm / metabolism*
Female
Floxuridine / diagnostic use*
Fluorine Radioisotopes / diagnostic use
Glioma / metabolism*,  radionuclide imaging*
Humans
Male
Middle Aged
RNA, Neoplasm / metabolism*
Tomography, Emission-Computed
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Fluorine Radioisotopes; 0/RNA, Neoplasm; 50-91-9/Floxuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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