Document Detail

Clinical applicability of heart rate variability analysis by methods based on nonlinear dynamics.
MedLine Citation:
PMID:  12114847     Owner:  NLM     Status:  MEDLINE    
Analysis of heart rate (HR) variability has become an important widely used method for assessing cardiac autonomic regulation. Conventionally, HR variability has been analyzed with time and frequency domain methods. Analysis of HR dynamics by methods based on nonlinear systems theory has opened a novel approach for studying the abnormalities in HR behavior. Recent studies have shown that these measures, particularly scaling analysis methods of HR dynamics, are altered among various patients populations with cardiovascular diseases, and they provide prognostic information. Altered long-term scaling properties of HR dynamics and more random short-term HR fluctuation has been observed, e.g., among patients with previous myocardial infarction, and these alterations have been shown to be associated with increased mortality rate. A relatively large body of data indicate that altered scaling properties of R-R intervals are physiologically deleterious. These findings support the notion that some nonlinear methods, such as scaling and complexity measures, give clinically valuable information for risk stratification among various patient populations. This article provides a review of our current knowledge of the usefulness of dynamical measures of HR fluctuation.
Timo H Mäkikallio; Jari M Tapanainen; Mikko P Tulppo; Heikki V Huikuri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cardiac electrophysiology review     Volume:  6     ISSN:  1385-2264     ISO Abbreviation:  Card Electrophysiol Rev     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-07-12     Completed Date:  2003-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9708907     Medline TA:  Card Electrophysiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  250-5     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, University of Oulu, Oulu, Finland.
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MeSH Terms
Autonomic Nervous System / physiopathology
Electrocardiography, Ambulatory / methods*
Heart / innervation*,  physiology*
Heart Failure / blood,  physiopathology
Heart Rate / physiology*
Myocardial Infarction / physiopathology
Nonlinear Dynamics
Norepinephrine / blood,  physiology
Risk Assessment
Survival Analysis
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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