Document Detail


Clinical applicability of coronary atherosclerotic lesion characterization.
MedLine Citation:
PMID:  21072033     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Native coronary atherosclerosis (CAS) is a diffuse and progressive disease process that is occasionally associated with either clinical atherothrombosis and/or major adverse cardiac events (MACE) including: ST elevation myocardial infarction (STEMI), acute coronary syndromes without ST elevation (ACSWSTE), heart failure, cardiac arrest and sudden cardiac death. Both, the timing and coronary site responsible for the MACE are currently unpredictable. Cardiovascular investigators have engaged in the task of characterizing CAS lesions in order to enhance our knowledge of CAS pathophysiology. It was expected that the knowledge acquired will allow scientists and clinicians to develop effective strategies to detect and treat "vulnerable plaque" (VP) prior to the evolution of MACE. This review discusses the emerging data regarding the pathology and natural history of the VP and vulnerable patient and the progress made in characterizing atherosclerotic plaque instability and vulnerability. Future directions in the field of plaque characterization and their potential clinical and research applications are discussed.
Authors:
E Kaluski; A Waller; A Patel; C Gerula; J Maher; B Haider; M Klapholz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-11
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  -     ISSN:  0026-4725     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Cardiology, Department of Medicine, University Hospitaland New Jersey Medical School, Newark, NJ, USA - kalusked@umdnj.edu.
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