Document Detail

Clinical and angiographic results of dilatation procedures for symptomatic intracranial atherosclerotic disease.
MedLine Citation:
PMID:  15951406     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The authors determined the technical success and the clinical and angiographic results of angioplasty and/or stent placement for intracranial atherosclerotic disease (ICAD) at a tertiary-care referral hospital. METHODS: Angiographic and clinical outcomes occurring within the 1-month follow-up interval were recorded. Patients were followed up for a mean period of 20.5 +/- 9.2 months, and a neurovascular imaging study was performed in 18 of the 21 patients alive after a mean period of 19.7 +/- 9.2 months. Stroke-free survival and ipsilateral stroke-prevention rates were estimated using Kaplan Meier analyses. RESULTS: Twenty-four patients (mean age = 61.0 +/- 13.5 years; 15 were men) underwent 30 procedures for treatment of ICAD. The procedures included angioplasty (n = 18) and attempted primary stent placement (n = 14). In 2 procedures, angioplasty was performed in the same session after unsuccessful stent placement. There was immediate stenosis reduction (mean +/- SD) from 84% +/- 17% to 27% +/- 21%. The overall 1-month composite rate of major stroke, death, and major bleeding complications was 7% for the 30 procedures. Overall stroke-free survival at 36 months was estimated as 79% (95% confidence interval, 57%-91%), and the ipsilateral stroke-prevention rate was estimated to be 87% (95% confidence interval, 65%-95%). Among the 15 patients who underwent repeat angiography, restenosis requiring second intervention was observed in 1 patient. No restenosis could be identified in 3 patients who underwent computed tomographic or magnetic resonance angiography. CONCLUSION: This single-center study demonstrates the feasibility and effectiveness (for secondary stroke prevention) of angioplasty and/or stent placement for treatment of ICAD.
Adnan I Qureshi; M Fareed K Suri; Amir M Siddiqui; Stanley H Kim; Alan S Boulos; Andrew J Ringer; Demetrius K Lopes; Lee R Guterman; L Nelson Hopkins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  15     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-09-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-9     Citation Subset:  IM    
Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, USA.
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MeSH Terms
Angiography, Digital Subtraction
Angioplasty, Balloon*
Cerebral Angiography*
Feasibility Studies
Follow-Up Studies
Intracranial Arteriosclerosis / radiography*,  therapy*
Middle Aged
Stroke / prevention & control
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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