| Clinical and angiographic profile of patients with markedly elevated coronary calcium scores (>or=1000) detected by electron beam computed tomography. | |
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MedLine Citation:
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PMID: 15721844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to determine the clinical and angiographic profile of patients with extremely high coronary artery calcium scores (CACS; >or=1000) by electron beam computed tomography (EBCT). METHODS: All patients at Rush University Medical Center who had a calcium score >or=1000 and a coronary angiogram performed from 1997 to 2002 were identified using a prospectively collected database. The baseline demographics, symptom status, and degree of coronary stenosis by angiography and subsequent rate of coronary intervention were compared with that of patients with calcium scores <1000. RESULTS: The clinical and angiographic profile of patients with severe coronary calcification, detected by EBCT, revealed that patients with scores >or=1000 had a significantly higher prevalence of coronary stenosis >or=50% compared with patients with scores <1000 (97% vs. 57%, P<.001). The group with CACS >or=1000 was more likely to be male (90% vs. 75%, P=.027) and was older (64+/-8 vs. 59+/-10, P=.001) compared with the group with less severe calcification. Although there was a significantly higher rate of luminal stenosis detected by coronary angiography in the cohort with CACS >or=1000, there was no difference in subsequent percutaneous coronary intervention (PCI) and utilization of intracoronary stents between the two groups. CONCLUSIONS: A markedly elevated coronary calcium score (>or=1000) is correlated with increasing age and is associated with an increased likelihood of coronary stenosis >or=50%. However, the decision to perform coronary angiography in patients with severe coronary calcification should not be based solely on these findings, but should remain primarily dependent on the degree of ischemia detected by clinical and functional assessment. |
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Authors:
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Francis Q Almeda; Rima Shah; Shaun Senter; Thomas T Kason; Justin Haynie; James E Calvin; Clifford J Kavinsky; R Jeffrey Snell; Gary L Schaer; Vallerie V McLaughlin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular radiation medicine Volume: 5 ISSN: 1522-1865 ISO Abbreviation: Cardiovasc. Radiat. Med. Publication Date: 2004 Jul-Sep |
Date Detail:
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Created Date: 2005-02-21 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888865 Medline TA: Cardiovasc Radiat Med Country: United States |
Other Details:
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Languages: eng Pagination: 109-12 Citation Subset: IM |
Affiliation:
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Rush University Medical Center, Chicago, IL, USA. falmeda@aol.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary Calcinosis / radiography*, therapy Chi-Square Distribution Coronary Angiography Coronary Stenosis / radiography*, therapy Female Humans Logistic Models Male Middle Aged Prospective Studies Stents Tomography, X-Ray Computed Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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