Document Detail

Clinical and angiographic outcomes after percutaneous recanalization of chronic total saphenous vein graft occlusion using modern techniques.
MedLine Citation:
PMID:  21126616     Owner:  NLM     Status:  MEDLINE    
Poor long-term outcomes after percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) of saphenous vein grafts (SVGs) have been reported. However, limited data are available evaluating the use of modern techniques in this group. The aim of the present study was to assess the efficacy and long-term outcomes of PCI in SVG CTO with the routine use of embolic protection devices and drug-eluting stents. A retrospective cohort analysis was conducted of all consecutive patients undergoing PCI to SVG CTO from May 2002 to July 2009 at 2 centers. The indication for PCI was the presence of angina or silent ischemia with evidence of inducible ischemia after functional testing in the territory supplied by the SVG, despite optimal medical therapy. We identified 34 patients with SVG CTO. Of the 34 patients, 23 (68%) underwent successful SVG recanalization with stent implantation. An embolic protection device was used in 78% and 95% of stents implanted were drug-eluting stents. No in-hospital major adverse cardiac events occurred in the successful PCI group; one myocardial infarction occurred in the unsuccessful group. At follow-up (median 18.0 months, interquartile range 10.4 to 48.3), 1 case of myocardial infarction had occurred in the successful group. The in-stent restenosis rate was 68% (n = 13), of which 77% were focal, with target vessel revascularization in 61%. In conclusion, despite the relatively low procedural success rates, the clinical outcomes after successful PCI to SVG CTO with modern techniques were favorable. The repeat revascularization rates were high; however, graft patency was achievable in most after reintervention.
Rasha Al-Lamee; Alfonso Ielasi; Azeem Latib; Cosmo Godino; Massimo Ferraro; Francesco Arioli; Marco Mussardo; Daniela Piraino; Filippo Figini; Mauro Carlino; Matteo Montorfano; Alaide Chieffo; Antonio Colombo
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2010-10-26
Journal Detail:
Title:  The American journal of cardiology     Volume:  106     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1721-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
San Raffaele Scientific Institute, Milan, Italy.
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MeSH Terms
Angioplasty, Balloon, Coronary / methods*
Chronic Disease
Coronary Angiography / methods*
Coronary Artery Bypass / adverse effects
Coronary Restenosis / radiography*,  therapy
Follow-Up Studies
Graft Occlusion, Vascular / radiography*,  therapy
Middle Aged
Myocardial Ischemia / radiography,  surgery
Prospective Studies
Saphenous Vein / physiopathology,  transplantation*
Transplantation Tolerance*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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