Document Detail


Clinical, anamnestic and serological features of peach allergy in portugal.
MedLine Citation:
PMID:  19033734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Peach is a common food allergen source throughout Europe. The aim of this study was to characterize peach allergy in a Portuguese patient population. METHODS: Thirty peach-allergic patients confirmed by double-blind placebo-controlled food challenges and 29 controls were included. All subjects completed a standardized questionnaire regarding symptoms and epidemiologic characteristics, skin prick tests with inhalant allergens and foods as well as specific IgE antibodies to peach, recombinant peach allergens rPru p 1, rPru p 3, rPru p 4 and cross-reactive carbohydrate determinants. RESULTS: Thirty-seven percent of patients reported only oral allergy syndrome, while 37% reported generalized urticaria and/or angioedema, 17% localized contact urticaria and 10% anaphylaxis with peach. Sensitization to other Rosaceae fruits and tree nuts was present in 90 and 77% of the patients, respectively. Respiratory allergy history was associated with less severe symptoms (oral allergy syndrome or contact urticaria; p < 0.01) and positive skin prick test to peach peel or plum with more severe symptoms (urticaria and/or angioedema or anaphylaxis; p < 0.05). Ninety-seven percent were sensitized to Pru p 3, 13% to Pru p 4, 3% to Pru p 1 and 10% to cross-reactive carbohydrate determinants. Pru p 3 specific IgE was associated with Artemisia vulgaris sensitization and tree nut allergy (p < 0.05) but not with clinical severity. CONCLUSIONS: Half the patients reported systemic reactions to peach. Peach allergy appeared predominantly mediated by Pru p 3 but some patients were sensitized to Pru p 4. Applying a 0.10 kU(A)/l cutoff level, the diagnostic value of combining the 3 recombinant allergens was noteworthy, with 100% sensitivity and 90% specificity.
Authors:
Rodrigo Rodrigues-Alves; Anabela Lopez; Maria Conceição Pereira-Santos; Susana Lopes-Silva; Amélia Spínola-Santos; Célia Costa; Manuel Branco-Ferreira; Jonas Lidholm; Manuel Pereira-Barbosa
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Publication Detail:
Type:  Journal Article     Date:  2008-11-26
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  149     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Copyright Information:
2008 S. Karger AG, Basel.
Affiliation:
Serviço de Imunoalergologia, Centro Hospitalar de Lisboa Norte, Portugal. rodrigosralves@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / diagnostic use,  immunology*
Case-Control Studies
Cross Reactions / immunology
Female
Food Hypersensitivity / diagnosis,  epidemiology*,  immunology*
Humans
Immunoglobulin E / blood*
Male
Middle Aged
Portugal / epidemiology
Prunus / immunology*
Questionnaires
Skin Tests
Chemical
Reg. No./Substance:
0/Allergens; 0/Pru p 3 allergen; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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