Document Detail

Clinical analysis of postoperative venous thromboembolism risk factors in lung cancer patients.
MedLine Citation:
PMID:  22711667     Owner:  NLM     Status:  Publisher    
BACKGROUND AND OBJECTIVES: The objective of this study is to explore clinical risk factors for venous thromboembolism (VTE) in postoperative lung cancer patients in order to provide a basis for the prevention and treatment of postoperative VTE. METHODS: A total of 1,001 lung cancer patients were retrospectively analyzed. Each patient was confirmed with surgical pathology diagnosis and had a complete clinical and follow-up record. VTE was identified in a combination of spiral computed tomography (CT), pulmonary angiography, and color Doppler ultrasound. We used life table method to create an occurrence frequency curve of thrombosis. We also searched for high risk factors for postoperative VTE with Cox multivariate regression model and created frequency curves of thrombosis against different risk factors using Kaplan-Meier method. RESULTS: As of July 31, 2011, the median follow-up time is 25.73 ± 0.11 months (19.23-31.37). The cumulative frequency of VTE among 1,001 lung cancer patients is 2%, 3%, 4%, 5%, and 5.3% over 1, 3, 6, 12, and 30 months after the surgery. COX regression analysis showed that the hazard ratio of VTE occurrence in patients with incomplete resection relative to ones with complete resection is 9.867 (95% CI: 5.275-18.459, P = 0.000). And the hazard ratio of VTE occurrence is 3.472 (95% CI: 1.761-6.845, P = 0.000) in patients with anti-angiogenesis treatment compared to patients without such treatment. The hazard ratio of VTE occurrence is 2.808 (95% CI: 1.439-5.479, P = 0.002) in patients with EGFR-TKI treatment relative to patients without the treatment, and 7.520 (95% CI: 3.968-14.250, P = 0.000) in patients with an increase in D-dimer level relative to normal ones CONCLUSIONS: The highest incidence of VTE is within 1 month after lung cancer surgery. High risk factors for VTE include incomplete surgical resection, postoperative use of anti-angiogenesis drugs, EGFR-TKI application and an increase in preoperative D-dimer level. J. Surg. Oncol © 2012 Wiley Periodicals, Inc.
Yi Yang; Zhen Zhou; Xiao-Min Niu; Zi-Ming Li; Zhi-Wei Chen; Hong Jian; Xing-Hao Ai; Bai-Jun Cheng; Mei-Lin Liao; Shun Lu
Related Documents :
23381917 - 'the sneaky plica' revisited: morphology, pathophysiology and treatment of synovial pli...
23623287 - Oxidant/antioxidant status in cases of snake bite.
22075337 - Percutaneous sclerotherapy in neonatal and infant head and neck lymphatic malformations...
17984737 - The effect of aminophylline on renal colic: a randomized double blind controlled trial.
23860937 - Ultrasound-assisted thrombolysis in submassive and massive pulmonary embolism: assessme...
18423747 - Alfuzosin stone expulsion therapy for distal ureteral calculi: a double-blind, placebo ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-18
Journal Detail:
Title:  Journal of surgical oncology     Volume:  -     ISSN:  1096-9098     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rise Time Perception in Children With Reading and Combined Reading and Language Difficulties.
Next Document:  Comparing model-based and model-free analysis methods for QUASAR arterial spin labeling perfusion qu...