Document Detail

Clinical analysis of high serum IgE in autoimmune pancreatitis.
MedLine Citation:
PMID:  21049558     Owner:  NLM     Status:  MEDLINE    
AIM: To clarify the clinical significance of high serum IgE in autoimmune pancreatitis (AIP).
METHODS: Forty-two AIP patients, whose IgE was measured before steroid treatment, were analyzed. To evaluate the relationship between IgE levels and the disease activity of AIP, we examined (1) Frequency of high IgE (> 170 IU/mL) and concomitant allergic diseases requiring treatment; (2) Correlations between IgG, IgG4, and IgE; (3) Relationship between the presence of extrapancreatic lesions and IgE; (4) Relationship between clinical relapse and IgE in patients treated with steroids, and (5) Transition of IgE before and after steroid treatment.
RESULTS: IgE was elevated in 36/42 (86%) patients. Concomitant allergic disease was observed in seven patients (allergic rhinitis in three, bronchial asthma in three, and urticaria in one). There were no significant correlations between IgG, IgG4, and IgE (r = -0.168 for IgG, and r = -0.188 for IgG4). There was no significant difference in IgE in the patients with and without extrapancreatic lesions (526 ± 531 IU/mL vs 819 ± 768 IU/mL, P = 0.163), with and without clinical relapse (457 ± 346 IU/mL vs 784 ± 786 IU/mL, P = 0.374). There was no significant difference in IgE between before and after steroid treatment (723 ± 744 IU/mL vs 673 ± 660 IU/mL, P = 0.633).
CONCLUSION: Although IgE does not necessarily reflect the disease activity, IgE might be useful for the diagnosis of AIP in an inactive stage.
Kenji Hirano; Minoru Tada; Hiroyuki Isayama; Kazumichi Kawakubo; Hiroshi Yagioka; Takashi Sasaki; Hirofumi Kogure; Yousuke Nakai; Naoki Sasahira; Takeshi Tsujino; Nobuo Toda; Kazuhiko Koike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-04     Completed Date:  2011-02-07     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5241-6     Citation Subset:  IM    
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MeSH Terms
Autoimmune Diseases / blood*,  drug therapy,  immunology*,  pathology
Hypersensitivity / blood,  immunology,  prevention & control
Immunoglobulin E / blood*
Immunoglobulin G / blood,  immunology
Middle Aged
Pancreatitis / blood*,  drug therapy,  immunology*,  pathology
Steroids / therapeutic use
Reg. No./Substance:
0/Immunoglobulin G; 0/Steroids; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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