Document Detail

Clinical analgesic efficacy and side effects of dexmedetomidine in the early postoperative period after arthroscopic knee surgery.
MedLine Citation:
PMID:  18083469     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To determine the analgesic efficacy of dexmedetomidine in the early postoperative period. DESIGN: Randomized, double-blind, double placebo-controlled clinical trial. SETTING: University medical center. PATIENTS: 30 ASA physical status I, II, and III patients with cruciate ligament lesion and joint fibrosis who were scheduled for knee arthroscopy. INTERVENTIONS: Patients were prospectively randomized to receive dexmedetomidine one mcg/kg(-1) intravenously (IV), for 10 minutes followed by dexmedetomidine 0.3 mcg/kg(-1) for 50 minutes or propacetamol two g, IV, for 10 minutes. MEASUREMENTS: Pain scores, time to onset analgesia, and morphine consumption were measured. Open-label rescue morphine 5 mg IV was available as needed during the postdosing evaluation period of 8 hours. Hemodynamic data, sedation scores, and renal and hepatic function were assessed for control of adverse events. MAIN RESULTS: Pain scores with dexmedetomidine and propacetamol were similar. There were no differences in the number of patients who required supplemental rescue analgesia (7/15 vs 4/15; P = 0.44), but total morphine requirements were higher with dexmedetomidine (45 mg) versus propacetamol (20 mg) in the 8-hour follow-up (P < 0.05). The most frequent adverse events with dexmedetomidine were bradycardia and hypertension. CONCLUSIONS: Dexmedetomidine provides a modest analgesic effect after knee arthroscopy, but the side effects of this drug, such as hypertension and bradycardia, may restrict the use of large bolus doses.
Maria E Gómez-Vázquez; Eduardo Hernández-Salazar; Abel Hernández-Jiménez; Arturo Pérez-Sánchez; Vilma A Zepeda-López; Mario Salazar-Páramo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  19     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-82     Citation Subset:  IM    
Department of Anesthesiology, HGR No 110, Instituto Mexicano del Seguro Social and CUCS, Universidad de Guadalajara, Guadalajara 44700, Mexico.
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MeSH Terms
Acetaminophen / administration & dosage,  analogs & derivatives
Analgesia / adverse effects,  methods*
Analgesics, Non-Narcotic / adverse effects,  therapeutic use*
Analgesics, Opioid / administration & dosage
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Arthroscopy / methods*
Blood Pressure / drug effects
Bradycardia / chemically induced
Dexmedetomidine / adverse effects,  therapeutic use*
Double-Blind Method
Follow-Up Studies
Heart Rate / drug effects
Hypertension / chemically induced
Knee Joint / surgery*
Middle Aged
Morphine / administration & dosage
Pain Measurement / drug effects,  statistics & numerical data
Pain, Postoperative / etiology,  prevention & control*
Postoperative Period
Prospective Studies
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 103-90-2/Acetaminophen; 113775-47-6/Dexmedetomidine; 57-27-2/Morphine; 66532-86-3/propacetamol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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