| Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series. | |
| | |
MedLine Citation:
|
PMID: 23292310 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients. |
| | |
Authors:
|
Antoine Italiano; Michèle Kind; Angela Cioffi; Robert G Maki; Binh Bui |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-6 |
Journal Detail:
|
Title: Targeted oncology Volume: - ISSN: 1776-260X ISO Abbreviation: Target Oncol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101270595 Medline TA: Target Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medical Oncology, Institut Bergonie, 229 Cours de l'Argonne, 33076, Bordeaux, France, a.italiano@bordeaux.unicancer.fr. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prognostic and therapeutic relevance of the IGF pathway in Ewing's sarcoma patients.
Next Document: Hydrophosphination of vinyl-boranes with phosphinoamines.