| Clinical acceptability of monophasic gestodene. | |
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MedLine Citation:
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PMID: 2220965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The monophasic low-dose contraceptive containing 30 micrograms of ethinyl estradiol and 75 micrograms of gestodene has been tested in numerous clinical studies to determine contraceptive reliability, cycle control, and influence on metabolism and to uncover concomitant symptoms. Clinical data have been derived from continuous phase III studies. Now that the preparation has been introduced in several countries, the opportunity to assemble comprehensive experience has been taken by initiating phase IV studies. Documentation on 600,000 therapy cycles with monophasic gestodene among 100,000 women is already available. The drop-out rate was low. A large number of women participated in the clinical studies for a long time--some up to 3 years. Study results showed that contraceptive reliability was high and cycle control was excellent. The gestodene combination was well tolerated. The frequency of concomitant symptoms was low. The monophasic gestodene meets the basic criteria essential for an oral contraceptive. |
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Authors:
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B Düsterberg; K Brill |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 163 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-11-19 Completed Date: 1990-11-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1398-404 Citation Subset: AIM; IM |
Affiliation:
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Research Laboratories, Schering AG, Berlin, West Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Body Weight / drug effects Contraceptives, Oral, Combined* / adverse effects, chemistry Drug Evaluation Ethinyl Estradiol* / adverse effects, chemistry Female Humans Menstrual Cycle / drug effects Norpregnenes* / adverse effects, chemistry Patient Dropouts Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Combined; 0/Norpregnenes; 57-63-6/Ethinyl Estradiol; 60282-87-3/Gestodene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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