Document Detail

Clinical value of serum neopterin, tissue polypeptide-specific antigen and CA19-9 levels in differential diagnosis between pancreatic cancer and chronic pancreatitis.
MedLine Citation:
PMID:  21242708     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neopterin and tissue polypeptide-specific antigen (TPS) have been suggested to be useful in differential diagnosis between pancreatic adenocarcinoma (PA) and chronic pancreatitis (CP). The aim of our study was to compare the clinical usefulness of CA19-9, neopterin and TPS serum levels in patients with PA and CP.
METHODS: The study included 85 patients with PA, 72 with CP and 50 healthy controls. The serum concentrations of neopterin, TPS and CA19-9 were measured (DRG International, USA). The associations of the analyzed markers and clinical data at diagnosis have been evaluated.
RESULTS: Serum levels of neopterin, TPS and CA19-9 were higher in PA patients compared to CP (p < 0.001). TPS and CA19-9 levels were also elevated in patients with CP compared to the control group (p < 0.001). In contrast, there was no difference between neopterin serum levels in CP patients and the control group (p > 0.05). Neopterin showed the best sensitivity and specificity (91.8 and 87.5%) in PA diagnosis compared to CA19-9 (respectively 83.5 and 75%) and TPS (75.3 and 65.3%).
CONCLUSION: Our results indicate that neopterin may be potentially useful in differential diagnosis between PA and CP. Assessment of TPS probably adds no significant information to that obtained with CA19-9 and neopterin. and IAP.
Renata Talar-Wojnarowska; Anita Gasiorowska; Marek Olakowski; Andrzej Lekstan; Paweł Lampe; Ewa Malecka-Panas
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Publication Detail:
Type:  Journal Article     Date:  2011-01-18
Journal Detail:
Title:  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]     Volume:  10     ISSN:  1424-3911     ISO Abbreviation:  Pancreatology     Publication Date:  2010  
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-19     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  100966936     Medline TA:  Pancreatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  689-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
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MeSH Terms
Adenocarcinoma / blood*,  diagnosis
Aged, 80 and over
CA-19-9 Antigen / blood*
Diagnosis, Differential
Middle Aged
Neopterin / blood*
Pancreatic Neoplasms / blood*,  diagnosis
Pancreatitis, Chronic / blood*,  diagnosis
Peptides / blood*
Predictive Value of Tests
ROC Curve
Tumor Markers, Biological / blood*
Young Adult
Reg. No./Substance:
0/CA-19-9 Antigen; 0/Peptides; 0/Tumor Markers, Biological; 0/tissue polypeptide specific antigen; 670-65-5/Neopterin

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