Document Detail


Clinical Value of [(11)C]Methionine PET for Stereotactic Radiation Therapy With Intensity Modulated Radiation Therapy to Metastatic Brain Tumors.
MedLine Citation:
PMID:  22520479     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: This study investigated the clinical impact of (11)C-labeled methionine-positron emission tomography (MET-PET) for stereotactic radiation therapy with intensity modulated radiation therapy (SRT-IMRT) in metastatic brain tumors. METHODS AND MATERIALS: Forty-two metastatic brain tumors were examined. All tumors were treated with SRT-IMRT using a helical tomotherapy system. Gross tumor volume (GTV) was defined and drawn on the stereotactic magnetic resonance (MR) image, taking into account the respective contributions of MR imaging and MET-PET. Planning target volume (PTV) encompassed the GTV-PET plus a 2-mm margin. SRT-IMRT was performed, keeping the dose for PTV at 25-35 Gy in 5 fractions. The ratio of the mean value of MET uptake to the contralateral normal brain (L/N ratio) was plotted for the PTV prior to SRT-IMRT, at 3 months following SRT-IMRT, and at 6 months following SRT-IMRT. Tumor characteristic changes of MET uptake before and after SRT-IMRT were evaluated quantitatively, comparing them with MRI examination. RESULTS: Mean ± SD L/N ratios were 1.95 ± 0.83, 1.18 ± 0.21, and 1.12 ± 0.25 in the pre-SRT-IMRT group, in the 3 months post-SRT-IMRT group, and in the 6 months post-SRT-IMRT group, respectively. Differences in the mean L/N ratio between the pre-SRT-IMRT group and the 3-month post-SRT-IMRT group and between the pre-SRT-IMRT group and the 6 month post-SRT-IMRT group were statistically significant, irrespective of MRI examination. CONCLUSIONS: We showed examples of metastatic lesions demonstrating significant decreases in MET uptake following SRT-IMRT. MET-PET seems to have a potential role in providing additional information, although MRI remains the gold standard for diagnosis and follow-up after SRT-IMRT. The present study is a preliminary approach, but to more clearly define the impact of PET-based radiosurgical assessment, further experimental and clinical analyses are required.
Authors:
Kazuhiro Miwa; Masayuki Matsuo; Jun Shinoda; Tatsuki Aki; Shingo Yonezawa; Takeshi Ito; Yoshitaka Asano; Mikito Yamada; Kazutoshi Yokoyama; Jitsuhiro Yamada; Hirohito Yano; Toru Iwama
Related Documents :
11703239 - Presence of protein deposits on 'cleaned' re-usable anaesthetic equipment.
15489489 - Incremental nature of anterior eye grading scales determined by objective image analysis.
11044029 - Osteochondritis dissecans of the tibial plafond: imaging characteristics and a review o...
19530259 - Characterization of engineered tissue construct mechanical function by magnetic resonan...
16621619 - Preliminary study on diffraction enhanced radiographic imaging for a canine model of ca...
17986979 - The evaluation of articular cartilage in magnetic resonance imaging.
2672219 - Ultrasound-guided biopsy.
11935199 - Sonography of injury of the posterior cruciate ligament of the knee.
11936489 - Contribution of cervical cord mri and brain magnetization transfer imaging to the asses...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  -     ISSN:  1879-355X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo, Gifu, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Gifu, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Molecular Profiling to Optimize Treatment in Non-Small Cell Lung Cancer: A Review of Potential Molec...
Next Document:  Excellence in Radiation Research for the 21st Century (EIRR21): Description of an Innovative Researc...