Document Detail

Clinical utility of the protein S100B to evaluate traumatic brain injury in the presence of acute alcohol intoxication.
MedLine Citation:
PMID:  22411109     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the role of the protein S100B as a biomarker for traumatic brain injury (TBI) in the presence of acute alcohol intoxication.
PARTICIPANTS: A total of 159 patients who presented to a large urban level 1 trauma center in Vancouver, British Columbia, Canada, were included. Patients were classified into 4 clinical groups-medical controls (MC), trauma controls (TC), uncomplicated mild TBI (MTBI), and definite TBI (DTBI)-and 2 day-of-injury alcohol intoxication groups (ie, sober and intoxicated).
PROCEDURE: Blood samples were collected within 8 hours of injury.
MAIN OUTCOME MEASURE: Protein S100B concentration (μg/L; Sangtec 100 Elisa, DiaSorin, Stillwater, Minnesota).
RESULTS: Higher S100B levels were found in patients who sustained a TBI than in those in the MC and TC groups (DTBI & MTBI >TC & MC). There was a positive linear relation between S100B levels and brain injury severity (DTBI > MTBI). Alcohol consumption at the time of injury did not generally affect S100B levels. The S100B levels had medium diagnostic accuracy for the majority of patients, with the exception of the DTBI-sober group in which S100B levels had very high diagnostic accuracy.
CONCLUSION: Patients with uncomplicated MTBIs and DTBIs had much higher levels of S100B than MC and TC participants. This biomarker had medium diagnostic accuracy for detecting DTBI in the presence of alcohol intoxication and very high accuracy in sober patients.
Rael T Lange; Grant L Iverson; Jeffrey R Brubacher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of head trauma rehabilitation     Volume:  27     ISSN:  1550-509X     ISO Abbreviation:  J Head Trauma Rehabil     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-06-25     Revised Date:  2012-10-11    
Medline Journal Info:
Nlm Unique ID:  8702552     Medline TA:  J Head Trauma Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-34     Citation Subset:  IM    
Defense and Veterans Brain Injury Center, Rockville, MD 20852, USA.
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MeSH Terms
Alcoholic Intoxication / blood*,  complications
Biological Markers / blood
Brain Injuries / blood*,  complications
Middle Aged
Nerve Growth Factors / blood*
S100 Proteins / blood*
Reg. No./Substance:
0/Biological Markers; 0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins

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