| The Clinical Utility of Kidney Injury Molecule 1 in the Prediction, Diagnosis and Prognosis of Acute Kidney Injury: A Systematic Review. | |
| | |
MedLine Citation:
|
PMID: 21539514 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: This systematic review evaluates the clinical utility of a novel biomarker kidney injury molecule 1 (Kim-1) in the prediction, diagnosis and prognosis of acute kidney injury (AKI). Methods: We searched literature in electronic databases from January 2002 to December 2009 by the key words "kidney injury molecule 1" or "Kim-1" and "acute kidney injury" or "acute renal failure". Studies were eligible for inclusion if they were primary studies published in English, in which Kim-1 was measured for the purpose of prediction, diagnosis or prognosis of AKI in patients. Results: Eight articles met the selection criteria for inclusion in the study. Compared to non AKI patients, Kim-1 increased significantly (at least p<0.05) in AKI patients by 2 hours after cardiac surgery. In the prediction of AKI in patients within 24 hours of cardiac surgery, the sensitivity of Kim-1 ranged from 92% to 100% and AUC between 0.78 and 0.91. Kim-1 increased significantly (at least p<0.05) in AKI established patients, especially in patients with acute tubular necrosis (ATN). The AUC of Kim-1 in the diagnosis of AKI was from 0.9 to 0.95. However, Kim-1 showed weak association with the need of renal replacement therapy and death of AKI patient. Conclusions: Kim-1 is a potential novel urinary biomarker in the early detection of AKI within 24 hours after kidney insult. It might be especially beneficial in the diagnosis of ischemic ATN. |
| | |
Authors:
|
Yun Huang; Andrew Craig Don-Wauchope |
Related Documents
:
|
185334 - Lipid abnormalities in hereditary neuropathy. part i. serum non-polar lipids. 9298344 - Electrophysiological investigations and prognosis in idiopathic facial palsy. 9462064 - A comparative study: classical, akinosi, and gow-gates techniques of mandibular nerve b... 17368544 - Prevalence of optic nerve edema in patients on peripheral hemodialysis. 12119934 - Cyclophosphamide and the prepubertal gonad: a negative report. 22919874 - Reibergram and oligoclonal bands in diagnosis of multiple sclerosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-4 |
Journal Detail:
|
Title: Inflammation & allergy drug targets Volume: - ISSN: 1871-5281 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101266886 Medline TA: Inflamm Allergy Drug Targets Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, L8S 4J9, Ontario, Canada. yun.huang@medportal.ca. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pentraxins: CRP and PTX3 and Cardiovascular Disease.
Next Document: Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a New Biomarker for Non - Acute Kidney Injury (...