Document Detail

The Clinical Utility of Kidney Injury Molecule 1 in the Prediction, Diagnosis and Prognosis of Acute Kidney Injury: A Systematic Review.
MedLine Citation:
PMID:  21539514     Owner:  NLM     Status:  Publisher    
Objective: This systematic review evaluates the clinical utility of a novel biomarker kidney injury molecule 1 (Kim-1) in the prediction, diagnosis and prognosis of acute kidney injury (AKI). Methods: We searched literature in electronic databases from January 2002 to December 2009 by the key words "kidney injury molecule 1" or "Kim-1" and "acute kidney injury" or "acute renal failure". Studies were eligible for inclusion if they were primary studies published in English, in which Kim-1 was measured for the purpose of prediction, diagnosis or prognosis of AKI in patients. Results: Eight articles met the selection criteria for inclusion in the study. Compared to non AKI patients, Kim-1 increased significantly (at least p<0.05) in AKI patients by 2 hours after cardiac surgery. In the prediction of AKI in patients within 24 hours of cardiac surgery, the sensitivity of Kim-1 ranged from 92% to 100% and AUC between 0.78 and 0.91. Kim-1 increased significantly (at least p<0.05) in AKI established patients, especially in patients with acute tubular necrosis (ATN). The AUC of Kim-1 in the diagnosis of AKI was from 0.9 to 0.95. However, Kim-1 showed weak association with the need of renal replacement therapy and death of AKI patient. Conclusions: Kim-1 is a potential novel urinary biomarker in the early detection of AKI within 24 hours after kidney insult. It might be especially beneficial in the diagnosis of ischemic ATN.
Yun Huang; Andrew Craig Don-Wauchope
Related Documents :
10604664 - Ulnar neuropathy as a complication of macular hole surgery.
1315474 - A clinical, electrophysiological, morphological and immunological study of chronic sens...
10540034 - Mri of the cauda equina in cidp: clinical correlations.
17031324 - Infective causes of facial nerve paralysis.
25376624 - Platelet-derived growth factor receptor-β expression in human peritoneum.
23521544 - Hemorrhagic transformation in patients with acute ischaemic stroke and an indication fo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-4
Journal Detail:
Title:  Inflammation & allergy drug targets     Volume:  -     ISSN:  1871-5281     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266886     Medline TA:  Inflamm Allergy Drug Targets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, L8S 4J9, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pentraxins: CRP and PTX3 and Cardiovascular Disease.
Next Document:  Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a New Biomarker for Non - Acute Kidney Injury (...