| Clinical Utility of Functional Imaging with 18F-FDOPA in Von Hippel-Lindau Syndrome. | |
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MedLine Citation:
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PMID: 22259055 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Von Hippel-Lindau (VHL) syndrome is an inherited cancer syndrome in which patients are at risk of developing multiple tumors in different organs. 6-L-(18)F-fluorodihydroxyphenylalanine ((18)F-FDOPA) positron emission tomography (PET) is a relatively new metabolic imaging tracer proposed for the use of localizing sites of neuroendocrine tumors. There are limited data on the clinical utility of using (18)F-FDOPA PET for identifying neuroendocrine tumors in a high-risk population such as VHL.Objective:The aim of this prospective study was to evaluate the clinical utility of (18)F-FDOPA PET in patients with VHL-related tumors.Design:Radiological findings were prospectively collected from four imaging modalities: computed tomography, magnetic resonance imaging (MRI), (18)F-fluorodeoxyglucose PET, and (18)F-FDOPA PET. (18)F-FDOPA PET findings were compared with those from other imaging modalities, as well as with clinical and laboratory data, and pathology findings if patients underwent an operation.Results:In 52 patients with VHL, 390 lesions were identified by computed tomography (n = 139), MRI (n = 117), (18)F-fluorodeoxyglucose PET (n = 94), and (18)F-FDOPA PET (n = 40). (18)F-FDOPA PET identified 20 pancreatic and 20 extrapancreatic tumors, including lesions in the adrenal gland (n = 11), kidney (n = 3), liver (n = 4), lung (n = 1), and cervical paraganglioma (n = 1). These tumor sites were not seen by conventional imaging studies in 9.6% of patients and 4.4% of lesions. Seven of eight patients who had an (18)F-FDOPA PET-positive lesion underwent resection, and pathology showed a neuroendocrine tumor. Four of 10 patients with positive adrenal uptake had elevated catecholamine levels, and six of 10 patients had a discrete mass on axial imaging.Conclusions:(18)F-FDOPA PET is a useful complementary imaging study to detect neuroendocrine tumors in patients with VHL undergoing surveillance, especially in those suspected to have adrenal pheochromocytoma or unusual ectopic locations. |
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Authors:
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Allison B Weisbrod; Mio Kitano; Krisana Gesuwan; Corina Millo; Peter Herscovitch; Naris Nilubol; W Marston Linehan; Electron Kebebew |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Endocrine Oncology Section, Surgery Branch (A.B.W., M.K., K.G., N.N., E.K.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; Department of Nuclear Medicine (C.M., P.H.), Positron Emission Tomography Imaging Section, National Institute of Health, Bethesda, Maryland 20892; and Urologic Oncology Branch (W.M.L.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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