Document Detail

Clinical Use of Interferon-gamma.
MedLine Citation:
PMID:  20074276     Owner:  NLM     Status:  MEDLINE    
Interferon gamma (IFN-gamma), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN-gamma and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN-gamma has been used in a wide variety of clinical indications, which are reviewed in this article.
Catriona H T Miller; Stephen G Maher; Howard A Young
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1182     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-79     Citation Subset:  IM    
Center for Cancer Research, Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.
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MeSH Terms
Adaptive Immunity
Immunity, Innate
Interferon-gamma / immunology*,  therapeutic use*
Grant Support
HHSN261200800001E//PHS HHS
Reg. No./Substance:

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