| The Clinical Significance of Coagulation and the Inflammatory Response in Autoimmunity. | |
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MedLine Citation:
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PMID: 21221848 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Maintenance of normal blood flow requires equilibrium between procoagulant and anticoagulant factors; occasionally, procoagulant activity predominates, leading to clot formation; frequently, tissue damage is the triggering factor. Hereditary factors, primary or acquired, play a role in the development of thrombosis. Primary thrombophilia is associated with hereditary factors, which promote hypercoagulability because natural anticoagulants are not exerting their activity. On the other hand, acquired thrombophilia may occur associated to autoimmune diseases, cancer, surgical procedures, pregnancy, postpartum period, and obesity. Activation of the coagulation system is characterized by the co-participation of inflammatory response components, factors related to the subjacent disease, and other procoagulant factors. The study of patients with thrombosis should include both inflammatory and autoimmune response markers. |
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Authors:
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Benjamín Rubio-Jurado; Paulina Iñiguez-Franco; Pedro A Reyes; Gustavo Robles; Mario Salazar-Páramo; Guadalupe Zavala-Cerna; Carlos Riebeling; Arnulfo Nava |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-8 |
Journal Detail:
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Title: Clinical reviews in allergy & immunology Volume: - ISSN: 1559-0267 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504368 Medline TA: Clin Rev Allergy Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Unidad de Investigación en Epidemiología Clínica, UMAE HE CMNO IMSS, Guadalajara, Jalisco, México. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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