| Clinical safety and efficacy of a novel thermoreversible polyhexanide-preserved wound covering gel. | |
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MedLine Citation:
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PMID: 20090348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An ideal topical formulation for wound therapy does not exist. The aim of this study was to develop a novel improved therapeutic option for the treatment of acute and chronic wounds. METHODS: A transparent wound gel which is in a liquid state below and in a gel state at or above room temperature was developed. Forty-four patients were included in this open randomized controlled single-center study. Flammazine served as control in the treatment of skin graft donor sites. Wounds were assessed for time of dressing change and overall satisfaction of patients and health care providers. The data were analyzed using the nonparametric Mann-Whitney test. RESULTS: The wound gel proved to be superior in comparison with Flammazine with respect to wound assessment (p = 0.002), staining (p = 0.007), leaking (p = 0.032) and smell (p = 0.034). Flammazine showed favorable results regarding the parameters dehydration of the dressings (p = 0.012) and wound adherence (p = 0.005). The evaluation of the overall dressing change process showed no significant differences. CONCLUSION: The thermoreversible wound gel containing polyhexanide allows for good handling and wound assessment. This study demonstrated a high satisfaction level of patient and health care providers, and the wound gel proved an effective alternative to commonly used treatments. |
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Authors:
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O Goertz; C Abels; U Knie; T May; T Hirsch; A Daigeler; H-U Steinau; S Langer |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-19 |
Journal Detail:
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Title: European surgical research. Europ?ische chirurgische Forschung. Recherches chirurgicales europ?ennes Volume: 44 ISSN: 1421-9921 ISO Abbreviation: Eur Surg Res Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 96-101 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la-Camp Platz 1, Bochum, Germany. ole.goertz@rub.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Infective Agents, Local / therapeutic use Bandages Biguanides / chemistry, therapeutic use* Female Gels Humans Informed Consent Male Middle Aged Ointments Patient Selection Safety Silver Sulfadiazine / chemistry, therapeutic use Skin Transplantation* Viscosity Wounds and Injuries / pathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Biguanides; 0/Gels; 0/Ointments; 22199-08-2/Silver Sulfadiazine; 51274-09-0/Vantocil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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