| Clinical Role of FDG PET/CT for Methotrexate-Related Malignant Lymphoma. | |
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MedLine Citation:
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PMID: 21637053 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Methotrexate-related malignant lymphoma (MTX-RML) is a type of therapy-related lymphoma, and it often occurs in patients with rheumatoid arthritis. The most distinctive characteristic of MTX-RML is a quick response to withdrawal of MTX. However, because there is a risk of recurrence without a distinctive indicator of disease, close follow-up is needed.We present F-18 2-fluoro-2-deoxyglucose (FDG) postitron emission tomography (PET) or computed tomography (CT) images of MTX-RML along with the characteristic clinical presentation of MTX-RML. FDG PET/CT has the advantage of being able to detect malignant lymphoma in patients who have undergone MTX treatment. After withdrawal of MTX, FDG uptake decreases along with a reduction in the volume of lesions. Although recurrent lesion develops independent to the initial FDG PET/CT findings, FDG PET/CT is useful for early detection of unexpected recurrent lesions.FDG PET/CT allows for the assessment of malignant lymphoma and recurrent lesions in patients who received MTX therapy, which is crucial for the management of MTX-RML. |
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Authors:
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Ryogo Minamimoto; Kimiteru Ito; Kazuo Kubota; Miyako Morooka; Yoko Masuda-Miyata; Risen Hirai; Hideaki Kitahara; Akira Tanimura; Shotaro Hagiwara; Akiyoshi Miwa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 533-7 Citation Subset: IM |
Affiliation:
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From the *Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan; †Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan; ‡Medicheck Imaging Center, Iwai Medical Foundation, Tokyo, Japan; and §Division of Hematology, Internal Medicine, National Center for Global Health and Medicine, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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