Document Detail

Clinical response to 2 commonly used switch formulas occurs within 1 day.
MedLine Citation:
PMID:  18832532     Owner:  NLM     Status:  MEDLINE    
Very fussy or extremely fussy infants were randomized to receive: soy-based formula (Soy: n = 82) or a partially hydrolyzed cow's milk protein (CMP), low-lactose formula (PHF: n = 77) in a multicenter, double-blind, randomized, parallel, prospective 28-day feeding trial. Body weight and infant formula tolerance were reported. Adverse events were recorded throughout the study. A significant reduction in mean scores of fussiness, gas, spit-up, and crying compared with baseline measures was observed in infants who received either Soy or PHF within 1 day of formula intake; improvement in symptoms was sustained by study end. Stool consistency remained constant through day 28 in the PHF group, whereas stools in the Soy group became more firm by day 2 and did not return to prestudy consistency. PHF, with a protein profile patterned more closely on human breast milk, improved symptoms of formula intolerance as well as soy-based formula.
Carol Lynn Berseth; William H Johnston; Suzanne I Stolz; Cheryl L Harris; Susan Hazels Mitmesser
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2008-10-02
Journal Detail:
Title:  Clinical pediatrics     Volume:  48     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  AIM; IM    
Mead Johnson Nutritionals, Evansville, Indiana 47721, USA.
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MeSH Terms
Double-Blind Method
Infant Behavior
Infant Formula*
Milk Proteins
Prospective Studies
Soy Milk
Reg. No./Substance:
0/Milk Proteins; 63-42-3/Lactose

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